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Article

Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System

1
Department of Otorhinolaryngology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
2
Department of Otorhinolaryngology, University Medical Center Bonn (UKB), Venusberg-Campus 1, 53127 Bonn, Germany
3
Max Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, Germany
4
Sustainable Polymer Chemistry, Department of Molecules and Materials, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, Universiteit Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands
5
Department of Otorhinolaryngology, Head and Neck Surgery, University of Tübingen, Elfriede-Aulhorn-Str. 5, 72076 Tübingen, Germany
6
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Obere Zahlbacher Str. 69, 55131 Mainz, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Mike Barbeck
Biomedicines 2021, 9(10), 1485; https://doi.org/10.3390/biomedicines9101485
Received: 31 August 2021 / Revised: 27 September 2021 / Accepted: 11 October 2021 / Published: 16 October 2021
Background: Porous polyethylene (PPE) implants are used for the reconstruction of tissue defects but have a risk of rejection in case of insufficient ingrowth into the host tissue. Various growth factors can promote implant ingrowth, yet a long-term gradient is a prerequisite for the mediation of these effects. As modification of the implant surface with nanocarriers may facilitate a long-term gradient by sustained factor release, implants modified with crosslinked albumin nanocarriers were evaluated in vivo. Methods: Nanocarriers from murine serum albumin (MSA) were prepared by an inverse miniemulsion technique encapsulating either a low- or high-molar mass fluorescent cargo. PPE implants were subsequently coated with these nanocarriers. In control cohorts, the implant was coated with the homologue non-encapsulated cargo substance by dip coating. Implants were consequently analyzed in vivo using repetitive fluorescence microscopy utilizing the dorsal skinfold chamber in mice for ten days post implantation. Results: Implant-modification with MSA nanocarriers significantly prolonged the presence of the encapsulated small molecules while macromolecules were detectable during the investigated timeframe regardless of the form of application. Conclusions: Surface modification of PPE implants with MSA nanocarriers results in the alternation of release kinetics especially when small molecular substances are used and therefore allows a prolonged factor release for the promotion of implant integration. View Full-Text
Keywords: porous polyethylene; biomaterial; material science; albumin nanocarriers; tissue engineering; release kinetics; dorsal skinfold chamber; fluorescence microscopy porous polyethylene; biomaterial; material science; albumin nanocarriers; tissue engineering; release kinetics; dorsal skinfold chamber; fluorescence microscopy
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MDPI and ACS Style

Eckrich, J.; Hoormann, N.; Kersten, E.; Piradashvili, K.; Wurm, F.R.; Heller, M.; Becker, S.; Anusic, T.; Brieger, J.; Strieth, S. Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System. Biomedicines 2021, 9, 1485. https://doi.org/10.3390/biomedicines9101485

AMA Style

Eckrich J, Hoormann N, Kersten E, Piradashvili K, Wurm FR, Heller M, Becker S, Anusic T, Brieger J, Strieth S. Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System. Biomedicines. 2021; 9(10):1485. https://doi.org/10.3390/biomedicines9101485

Chicago/Turabian Style

Eckrich, Jonas, Niklas Hoormann, Erik Kersten, Keti Piradashvili, Frederik R. Wurm, Martin Heller, Sven Becker, Toni Anusic, Juergen Brieger, and Sebastian Strieth. 2021. "Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System" Biomedicines 9, no. 10: 1485. https://doi.org/10.3390/biomedicines9101485

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