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Relapsing Polychondritis: An Updated Review

Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, Italy
Author to whom correspondence should be addressed.
Biomedicines 2018, 6(3), 84;
Received: 30 May 2018 / Revised: 23 July 2018 / Accepted: 25 July 2018 / Published: 2 August 2018
PDF [254 KB, uploaded 2 August 2018]


Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the diagnosis of relapsing polychondritis is often delayed. In this review article we provide a comprehensive look into clinical presentation, laboratory and instrumental investigations, diagnostic criteria, and therapeutic options. View Full-Text
Keywords: relapsing polychondritis; auricular chondritis; systemic autoimmune disease; cartilage; anti-type II collagen antibodies relapsing polychondritis; auricular chondritis; systemic autoimmune disease; cartilage; anti-type II collagen antibodies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Borgia, F.; Giuffrida, R.; Guarneri, F.; Cannavò, S.P. Relapsing Polychondritis: An Updated Review. Biomedicines 2018, 6, 84.

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