Next Article in Journal
Functionalisation of Polyvinylpyrrolidone on Gold Nanoparticles Enhances Its Anti-Amyloidogenic Propensity towards Hen Egg White Lysozyme
Next Article in Special Issue
In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
Previous Article in Journal
Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessArticle
Biomedicines 2017, 5(2), 18;

The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin

Department of Nutrition and Dietetics, High School of Health, Agri İbrahim Cecen University, Agri 04100, Turkey
Department of Medical Laboratory, Health Services Vocational Training School, Atatürk University, Erzurum 25240, Turkey
Department of Pathology, Faculty of Medicine, Atatürk University, Erzurum 25240, Turkey
Department of Biochemistry, Faculty of Pharmacy, Atatürk University, Erzurum 25240, Turkey
Department of Chemistry, Faculty of Science, Atatürk University, Erzurum 25240, Turkey
Authors to whom correspondence should be addressed.
Academic Editors: Solomon Habtemariam and Giovanni Lentini
Received: 19 February 2017 / Revised: 24 April 2017 / Accepted: 25 April 2017 / Published: 28 April 2017
(This article belongs to the Special Issue Plant Derived Biomedicines)
Full-Text   |   PDF [1047 KB, uploaded 11 May 2017]   |  


In this study, we aimed to investigate the effects of p-Coumaric acid (PCA) on cisplatin (CIS)-induced hepatotoxicity and nephrotoxicity in Wistar adult rats for 24 h compared to untreated control groups. In this experiment, 40 Wistar adult rats were utilized and divided randomly into five groups. After 24 h of CIS administration, liver and kidneys were harvested and assessed by H&E staining. Also, markers for oxidative stress and antioxidants were analyzed in theses tissues. Compared to the control group, accumulation of malondialdehyde was increased in groups treated CIS, whereas superoxide dismutase activities and glutathione levels were distinctly diminished in this group. The study’s histopathological findings such as hydropic degeneration, vascular congestion, sinusoidal dilatation in hepatocytes and tubular necrosis in kidneys were in accordance with the results of markers for oxidative stress. PCA may prevent hepatotoxicity and nephrotoxicity by increased antioxidant enzymes and reduced oxidant parameters. View Full-Text
Keywords: hepatotoxicity; nephrotoxicity; p-Coumaric acid; antioxidant activity; oxidative stress hepatotoxicity; nephrotoxicity; p-Coumaric acid; antioxidant activity; oxidative stress

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ekinci Akdemir, F.N.; Albayrak, M.; Çalik, M.; Bayir, Y.; Gülçin, İ. The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin. Biomedicines 2017, 5, 18.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top