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Primary Human Blood Dendritic Cells for Cancer Immunotherapy—Tailoring the Immune Response by Dendritic Cell Maturation

1
Department of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, GA Nijmegen 6525, The Netherlands
2
Department of Medical Oncology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, GA Nijmegen 6525, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Vincenzo Cerullo
Biomedicines 2015, 3(4), 282-303; https://doi.org/10.3390/biomedicines3040282
Received: 10 November 2015 / Revised: 23 November 2015 / Accepted: 25 November 2015 / Published: 2 December 2015
(This article belongs to the Special Issue Dendritic Cells and Cancer Immunotherapy)
Dendritic cell (DC)-based cancer vaccines hold the great promise of tipping the balance from tolerance of the tumor to rejection. In the last two decades, we have gained tremendous knowledge about DC-based cancer vaccines. The maturation of DCs has proven indispensable to induce immunogenic T cell responses. We review the insights gained from the development of maturation cocktails in monocyte derived DC-based trials. More recently, we have also gained insights into the functional specialization of primary human blood DC subsets. In peripheral human blood, we can distinguish at least three primary DC subsets, namely CD1c+ and CD141+ myeloid DCs and plasmacytoid DCs. We reflect the current knowledge on maturation and T helper polarization by these blood DC subsets in the context of DC-based cancer vaccines. The maturation stimulus in combination with the DC subset will determine the type of T cell response that is induced. First trials with these natural DCs underline their excellent in vivo functioning and mark them as promising tools for future vaccination strategies. View Full-Text
Keywords: human blood DC (dendritic cell) subsets; maturation; DC-based cancer vaccines; plasmacytoid DC; myeloid DC; CD141+ myeloid DC (mDC); CD1c+ mDC human blood DC (dendritic cell) subsets; maturation; DC-based cancer vaccines; plasmacytoid DC; myeloid DC; CD141+ myeloid DC (mDC); CD1c+ mDC
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Sittig, S.P.; De Vries, I.J.M.; Schreibelt, G. Primary Human Blood Dendritic Cells for Cancer Immunotherapy—Tailoring the Immune Response by Dendritic Cell Maturation. Biomedicines 2015, 3, 282-303.

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