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Correction

Correction: Cheng et al. NICEFIT—A Prospective, Non-Interventional, and Multicentric Study for the Management of Idiopathic Pulmonary Fibrosis with Antifibrotic Therapy in Taiwan. Biomedicines 2022, 10, 2362

1
Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan City 320, Taiwan
2
Department of Pulmonary, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan
3
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
5
Division of Clinical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan
6
Department of Thoracic Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
7
Department of Pulmonary, China Medical University Hospital, Taichung 404, Taiwan
8
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan
9
Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan
10
Department of Recreation and Holistic Wellness, MingDao University, Changhua 403, Taiwan
11
Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 403, Taiwan
12
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
13
Department of Medicine, National Taiwan University Cancer Center, Taipei 100, Taiwan
14
Department of Chest Medicine, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei Veterans General Hospital, Taipei 112, Taiwan
*
Authors to whom correspondence should be addressed.
Biomedicines 2025, 13(7), 1509; https://doi.org/10.3390/biomedicines13071509
Submission received: 9 January 2025 / Accepted: 22 January 2025 / Published: 20 June 2025
(This article belongs to the Section Molecular and Translational Medicine)
We would like to identify and amend errors in a previously published paper [1]. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Error in Figure

In the original publication, a component of Figure 2 (Figure 2d) was missing. The data values in the figure are published and cited in the original manuscript text (first paragraph from ‘secondary outcomes’ section). The corrected Figure 2 appears below.
Additionally, incorrect values were included in Figure 3c (the week 52 data value of 6 MWT). Correct values are reported in the original manuscript text (Table 6 and second paragraph from ‘secondary outcomes’ section). The corrected Figure 3 appears below.

Error in Table

In the original publication, there was a mistake in Tables 3–5 as published, in that 95% CI was incorrectly written as 95% C.I. There was an extra row in Table 3. The corrected Table 3, Table 4 and Table 5 appear below.

Text Correction

In the Results Section, Section 3.2.1., Figure 2a was mis-cited in the second sentence of paragraphs 1 and 2 and they should be Figure S1. The corrected sentences appear below.
The mean ± SD of absolute annual change from baseline in FVC was −114.3 ± 441.5 mL at week 52 and −142.5 ± 610.8 mL at week 100 (Figure S1).
There was no significant change from baseline (mean ± SD) for absolute DLCO, which ranged from −2.6 to 0.1 mL/min/mmHg (Figure S1) during the 2-year follow-up.
In the Discussion section, there was an error in the original publication. The “mean ± 1.7%” is updated to “±1.7%” in the first paragraph of the discussion for consistency with the results. The corrected sentence appears below.
Despite significantly compromised baseline functionality, antifibrotic therapy with nintedanib or pirfenidone limited further deteriorations of respiratory functions, especially with respect to annual changes from baseline in percent predicted FVC (±1.7%), without adversely affecting the quality of life.

Modifications in Author Contributions

The corrected Author Contributions appears below.
Conceptualization, S.-L.C., H.-C.W. and D.-W.P.; validation, H.-C.W. and D.-W.P.; investigation, S.-L.C., C.-C.S., C.-F.C., J.-Y.H., K.-C.K., L.-W.H., C.-H.L., W.-F.F., H.-C.W. and D.-W.P.; data curation, S.-L.C., C.-C.S., C.-F.C., J.-Y.H., K.-C.K., L.-W.H., C.-H.L., W.-F.F., H.-C.W. and D.-W.P.; writing—review and editing, S.-L.C.; visualization, S.-L.C., H.-C.W. and D.-W.P. All authors have read and agreed to the published version of the manuscript.

Reference

  1. Cheng, S.-L.; Sheu, C.-C.; Chian, C.-F.; Hsu, J.-Y.; Kao, K.-C.; Hang, L.-W.; Lin, C.-H.; Fang, W.-F.; Wang, H.-C.; Perng, D.-W. NICEFIT—A Prospective, Non-Interventional, and Multicentric Study for the Management of Idiopathic Pulmonary Fibrosis with Antifibrotic Therapy in Taiwan. Biomedicines 2022, 10, 2362. [Google Scholar] [CrossRef]
Figure 2. Changes in baseline of primary outcome parameters across the study period in the treated group. (a) Annual changes from baseline for the primary lung function parameters, (i) FVC, (ii) DLCO, (iii) SpO2, (iv) TLC, and (v) IC, as measured through spirometry. (b) Changes in percent predicted FVC from baseline. (c) Predicted mean and absolute FVC changes in survivors and non-survivors, treated with antifibrotic drugs, and (d) predicted mean and absolute FVC changes in treated patients experiencing versus not experiencing at least one acute exacerbation, stratified by emphysema status. AE, acute exacerbation; DLCO, diffusion of carbon monoxide in lungs; FVC, forced vital capacity; IC, inspiratory capacity; SpO2, oxygen saturation; pred, predicted; TLC, total lung capacity.
Figure 2. Changes in baseline of primary outcome parameters across the study period in the treated group. (a) Annual changes from baseline for the primary lung function parameters, (i) FVC, (ii) DLCO, (iii) SpO2, (iv) TLC, and (v) IC, as measured through spirometry. (b) Changes in percent predicted FVC from baseline. (c) Predicted mean and absolute FVC changes in survivors and non-survivors, treated with antifibrotic drugs, and (d) predicted mean and absolute FVC changes in treated patients experiencing versus not experiencing at least one acute exacerbation, stratified by emphysema status. AE, acute exacerbation; DLCO, diffusion of carbon monoxide in lungs; FVC, forced vital capacity; IC, inspiratory capacity; SpO2, oxygen saturation; pred, predicted; TLC, total lung capacity.
Biomedicines 13 01509 g002
Figure 3. Secondary outcome trends in the treated group. Secondary outcomes with respect to (a) SGRQ, (b) CAT, and (c,d) 6MWT were scored as annual changes from the baseline at the end of weeks 52 and 100 to assess health-related quality of life, airway obstruction and exercise-related pulmonary function, respectively. SGRQ, St. George’s respiratory questionnaire; CAT, chronic obstructive pulmonary disease assessment test; 6MWT, 6 min walk test.
Figure 3. Secondary outcome trends in the treated group. Secondary outcomes with respect to (a) SGRQ, (b) CAT, and (c,d) 6MWT were scored as annual changes from the baseline at the end of weeks 52 and 100 to assess health-related quality of life, airway obstruction and exercise-related pulmonary function, respectively. SGRQ, St. George’s respiratory questionnaire; CAT, chronic obstructive pulmonary disease assessment test; 6MWT, 6 min walk test.
Biomedicines 13 01509 g003
Table 3. Logistic regression analysis for death between weeks 0–104.
Table 3. Logistic regression analysis for death between weeks 0–104.
n/N (%)Odds Ratio (95% CI)p-Value
All treated patients28/88 (31.8)
Age (year)
<7513/49 (26.5)
≥7515/39 (38.5)1.891 (0.532, 6.726)0.325
Gender
Women2/17 (11.8)
Men26/71 (36.6)9.230 (0.826, 103.114)0.071
Smoking
Never14/41 (34.1)
Current or ex-smoker14/47 (29.8)1.049 (0.225, 4.889)0.951
BMI
<2723/61 (37.7)
≥275/27 (18.5)0.364 (0.075, 1.767)0.21
GAP stage at baseline
Stage I2/14 (14.3)
Stage II9/29 (31.0)0.936 (0.115, 7.600)0.951
Stage III17/44 (38.6)0.548 (0.061, 4.932)0.592
FVC (% pred.) at baseline
≥65%13/52 (25.0)
<65%15/35 (42.9)3.980 (0.994, 15.937)0.051
Emphysema at baseline
No24/73 (32.9)
Yes4/15 (26.7)0.411 (0.085, 1.986)0.269
Obstructive sleep apnea risk
Low risk4/15 (26.7)
Intermediate risk17/54 (31.5)0.281 (0.031, 2.571)0.261
High risk7/19 (36.8)0.312 (0.021, 4.643)0.398
Any comorbidity
None 3/10 (30.0)
Any25/78 (32.1)0.140 (0.012, 1.684)0.121
Cardiovascular-related comorbidity
None13/37 (35.1)
Any15/51 (29.4)0.823 (0.191, 3.551)0.794
Respirator-related comorbidity
None 9/36 (25.0)
Any19/52 (36.5)16.286 (1.996, 132.880)0.009
Bronchodilator use
No10/39 (25.6)
Yes18/49 (36.7)2.163 (0.564, 8.303)0.261
Decline in FVC (% pred.)
No 15/56 (26.8)
Yes8/23 (34.8)1.116 (0.245, 5.083)0.888
BMI, body mass index; CI, confidence interval; FVC, forced vital capacity; GAP, Gender, Age, Physiology; pred, predicted. A p-value < 0.05 is significant. Sleep apnea was evaluated according to the STOP-Bang scoring model. Variability in gender, smoke, GAP stage, risk associated with obstructive sleep apnea, or comorbidities were removed from the model where quasi-complete separation of data points were detected.
Table 4. Logistic regression analysis for acute exacerbation/death in treated patients between weeks 0–104.
Table 4. Logistic regression analysis for acute exacerbation/death in treated patients between weeks 0–104.
n/N (%)Odds Ratio (95% CI)p-Value
All treated patients40/88 (45.5)
Age (year)
<7518/49 (36.7)
≥7522/39 (56.4)1.882 (0.604, 5.866)0.275
Gender
Women4/17 (23.5)
Men36/71 (50.7)6.877 (0.880, 53.745)0.066
Smoking
Never21/41 (51.2)
Current or ex-smoker19/47 (40.4)0.530 (0.134, 2.087)0.364
BMI
<2733/61 (54.1)
≥277/27 (25.9)0.393 (0.105, 1.468)0.165
GAP stage at baseline
Stage I4/14 (28.6)
Stage II11/29 (37.9)0.713 (0.125, 4.063)0.703
Stage III25/44 (56.8)0.831 (0.135, 5.109)0.842
FVC (% pred.) at baseline
≥65%20/52 (38.5)
<65%20/35 (57.1)2.544 (0.740, 8.752)0.139
Emphysema at baseline
No34/73 (46.6)
Yes6/15 (40.0)0.470 (0.110, 2.002)0.307
Obstructive sleep apnea risk
Low risk5/15 (33.3)
Intermediate risk26/54 (48.1)0.362 (0.048, 2.697)0.321
High risk9/19 (47.4)0.278 (0.023, 3.341)0.313
Any comorbidity
None3/10 (30.0)
Any37/78 (47.4)0.737 (0.094, 5.800)0.772
Cardiovascular-related comorbidity
None15/37 (40.5)
Any25/51 (49.0)1.577 (0.426, 5.838)0.495
Respirator-related comorbidity
None14/36 (38.9)
Any26/52 (50.0)4.848 (1.147, 20.489)0.032 *
Bronchodilator use
No18/39 (46.2)
Yes22/49 (44.9)0.896 (0.290, 2.763)0.848
Decline in FVC (% pred.)
No22/56 (39.3)
Yes13/23 (56.5)1.203 (0.330, 4.383)0.779
BMI, body mass index; CI, confidence interval; FVC, forced vital capacity; GAP, Gender, Age, Physiology; pred, predicted. A * p-value < 0.05 is significant. Sleep apnea was evaluated according to the STOP-Bang scoring model. Variability in gender, smoke, GAP stage, risk associated with obstructive sleep apnea, or comorbidities were removed from the model where quasi-complete separation of data points were detected.
Table 5. Logistic regression analysis for acute exacerbation between weeks 53–104.
Table 5. Logistic regression analysis for acute exacerbation between weeks 53–104.
n/N (%)Odds Ratio (95% CI)p-Value
All treated patients5/88 (5.7)
Age (year)
<754/49 (8.2)
≥751/39 (2.6)0.235 (0.014, 3.826)0.309
BMI
<272/61 (3.3)
≥273/27 (11.1)3.978 (0.379, 41.798)0.25
FVC (% pred.) at baseline
≥65%3/52 (5.8)
<65%2/35 (5.7)2.276 (0.242, 21.443)0.472
Emphysema at baseline
No4/73 (5.5)
Yes1/15 (6.7)1.095 (0.059, 20.410)0.951
Cardiovascular-related comorbidity
None1/37 (2.7)
Any4/51 (7.8)6.488 (0.497, 84.764)0.154
Respirator-related comorbidity
None2/36 (5.6)
Any3/52 (5.8)0.097 (0.004, 2.415)0.155
Bronchodilator use
No1/39 (2.6)
Yes4/49 (8.2)8.860 (0.429, 183.081)0.158
Decline in FVC (% pred.)
No2/56 (3.6)
Yes3/23 (13.0)10.887 (1.033, 114.784)0.047
BMI, body mass index; FVC, forced vital capacity, GAP, Gender-Age-Physiology, pred, predicted. p-value < 0.05 is significant.
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MDPI and ACS Style

Cheng, S.-L.; Sheu, C.-C.; Chian, C.-F.; Hsu, J.-Y.; Kao, K.-C.; Hang, L.-W.; Lin, C.-H.; Fang, W.-F.; Wang, H.-C.; Perng, D.-W. Correction: Cheng et al. NICEFIT—A Prospective, Non-Interventional, and Multicentric Study for the Management of Idiopathic Pulmonary Fibrosis with Antifibrotic Therapy in Taiwan. Biomedicines 2022, 10, 2362. Biomedicines 2025, 13, 1509. https://doi.org/10.3390/biomedicines13071509

AMA Style

Cheng S-L, Sheu C-C, Chian C-F, Hsu J-Y, Kao K-C, Hang L-W, Lin C-H, Fang W-F, Wang H-C, Perng D-W. Correction: Cheng et al. NICEFIT—A Prospective, Non-Interventional, and Multicentric Study for the Management of Idiopathic Pulmonary Fibrosis with Antifibrotic Therapy in Taiwan. Biomedicines 2022, 10, 2362. Biomedicines. 2025; 13(7):1509. https://doi.org/10.3390/biomedicines13071509

Chicago/Turabian Style

Cheng, Shih-Lung, Chau-Chyun Sheu, Chih-Feng Chian, Jeng-Yuan Hsu, Kuo-Chin Kao, Liang-Wen Hang, Ching-Hsiung Lin, Wen-Feng Fang, Hao-Chien Wang, and Diahn-Warng Perng. 2025. "Correction: Cheng et al. NICEFIT—A Prospective, Non-Interventional, and Multicentric Study for the Management of Idiopathic Pulmonary Fibrosis with Antifibrotic Therapy in Taiwan. Biomedicines 2022, 10, 2362" Biomedicines 13, no. 7: 1509. https://doi.org/10.3390/biomedicines13071509

APA Style

Cheng, S.-L., Sheu, C.-C., Chian, C.-F., Hsu, J.-Y., Kao, K.-C., Hang, L.-W., Lin, C.-H., Fang, W.-F., Wang, H.-C., & Perng, D.-W. (2025). Correction: Cheng et al. NICEFIT—A Prospective, Non-Interventional, and Multicentric Study for the Management of Idiopathic Pulmonary Fibrosis with Antifibrotic Therapy in Taiwan. Biomedicines 2022, 10, 2362. Biomedicines, 13(7), 1509. https://doi.org/10.3390/biomedicines13071509

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