First Spanish Experience with Stereotactic MR-Guided Adaptive Radiotherapy (SMART) in Borderline Resectable and Locally Advanced Pancreatic Cancer: A Prospective Study
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Patient Selection
2.2. Simulation and Treatment Planning
Follow-Up and Outcome Assessment
- Local control (LC): Absence of progression in the primary tumor and regional lymph nodes (RECIST v1.1).
- Overall survival (OS): Time from diagnosis to death or last follow-up.
- Distant progression-free survival (DPFS): Time from diagnosis to first distant metastasis.
- Progression-free survival (PFS): Time from diagnosis to progression, death, or last contact.
- Treatment-free interval (TFI): Time from the last SMART fraction to the appearance of distant metastases.
2.3. Statistical Analysis
3. Results
3.1. Treatment Characteristics
3.2. Toxicity and Outcomes
3.3. Oncologic Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
SMART | Ablative Stereotactic MR-guided Adaptive Radiation Therapy |
BED | Biologically Effective Dose |
BRPC | Borderline Resectable Pancreatic Cancer |
bSSFP | Balanced Steady-State Free Precession |
CA 19-9 | Carbohydrate Antigen 19-9 |
CT | Computed Tomography |
CTCAE | Common Terminology Criteria for Adverse Events |
CTV | Clinical Target Volume |
DFFS | Distant Failure-Free Survival |
DIBH | Deep Inspiration Breath Hold |
DVH | Dose–Volume Histogram |
ECOG | Eastern Cooperative Oncology Group |
ENI | Elective Nodal Irradiation |
GTV | Gross Tumor Volume |
IMRT | Intensity-Modulated Radiation Therapy |
LAPC | Locally Advanced Pancreatic Cancer |
LC | Local Control |
MRI | Magnetic Resonance Imaging |
MRgRT | Magnetic Resonance-guided Radiotherapy |
MR-LINAC | Magnetic Resonance Linear Accelerator |
OAR | Organ at Risk |
OS | Overall Survival |
PDAC | Pancreatic Ductal Adenocarcinoma |
PET-CT | Positron Emission Tomography–Computed Tomography |
PFS | Progression-Free Survival |
PTV | Planning Target Volume |
PTV_High/PTV\_opt | High-dose Planning Target Volume (Optimized) |
PTV_Low | Low-dose Planning Target Volume |
RTT | Radiation Therapist |
SBRT | Stereotactic Body Radiation Therapy |
TFI | Treatment-Free Interval |
TRUFI | True Fast Imaging with Steady-State Precession |
ULN | Upper Limit of Normal |
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Organ at Risk (OAR) | Dose Constraint |
---|---|
Esophagus, Stomach, Duodenum, | V33 < 0.05 cc |
Small bowel | V30 < 5 cc |
Large Bowel | V52.3 < 0.035 cc |
V32.5 < 20 cc | |
Liver | Dmean < 15 Gy |
Aorta | V47 < 10 cc |
Spinal Cord | Dmax (0.035 cc) < 12 Gy |
Kidneys | V17.5 < 200 cc |
Characteristic | Value |
---|---|
Age, median (range) | 67 (43–86) |
Sex |
Male 17 (60.7%)
Female 11 (39.3%) |
Tumor location |
Head 20 (71.4%)
Body/Tail 8 (28.6%) |
ECOG |
0: 15 (53.6%)
1: 13 (46.4%) |
Stage |
Borderline: 7 (25%)
LAPC: 21 (75%) |
Clinical T |
T1: 1 (3.6%)
T2: 9 (32.1%) T3: 6 (21.4%) T4: 12 (42.9%) |
Tumor size, median (mm) | 32.7 (15–58) |
Clinical N |
0: 19 (67.9%)
1: 9 (32.1%) |
CA 19-9, median (U/mL) | 1029 (136–1923) |
Chemotherapy regimen |
FOLFIRINOX: 16 (57.1%)
Gemcitabine/Abraxane: 7 (24.6%) FOLFIRI: 1 (3.6%) Other: 4 (14.3%) |
Chemotherapy cycles, median | 6 (4–12) |
Radiation dose |
40 Gy: 9 (32.1%)
45 Gy: 5 (17.9%) 50 Gy: 14 (50%) |
Motion management |
DIBH: 23 (81.1%)
Free breathing: 5 (18.9%) |
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Gonsalves, D.; Ocanto, A.; Meilan, E.; Gomez, A.; Dominguez, J.; Torres, L.; Fernández, C.; Teja, M.; Garrido, I.; Gonzalez, M.; et al. First Spanish Experience with Stereotactic MR-Guided Adaptive Radiotherapy (SMART) in Borderline Resectable and Locally Advanced Pancreatic Cancer: A Prospective Study. Biomedicines 2025, 13, 2390. https://doi.org/10.3390/biomedicines13102390
Gonsalves D, Ocanto A, Meilan E, Gomez A, Dominguez J, Torres L, Fernández C, Teja M, Garrido I, Gonzalez M, et al. First Spanish Experience with Stereotactic MR-Guided Adaptive Radiotherapy (SMART) in Borderline Resectable and Locally Advanced Pancreatic Cancer: A Prospective Study. Biomedicines. 2025; 13(10):2390. https://doi.org/10.3390/biomedicines13102390
Chicago/Turabian StyleGonsalves, Daniela, Abrahams Ocanto, Eduardo Meilan, Alberto Gomez, Jesus Dominguez, Lisselott Torres, Castalia Fernández, Macarena Teja, Isabel Garrido, Maria Gonzalez, and et al. 2025. "First Spanish Experience with Stereotactic MR-Guided Adaptive Radiotherapy (SMART) in Borderline Resectable and Locally Advanced Pancreatic Cancer: A Prospective Study" Biomedicines 13, no. 10: 2390. https://doi.org/10.3390/biomedicines13102390
APA StyleGonsalves, D., Ocanto, A., Meilan, E., Gomez, A., Dominguez, J., Torres, L., Fernández, C., Teja, M., Garrido, I., Gonzalez, M., Gaztañaga, M., Herrero, D., Thuissard, I. J., Andreu, C., Gonzalez, T., González, J. A., Yagüe, J. A., Holgado, E., Alcaraz, D., ... Couñago, F. (2025). First Spanish Experience with Stereotactic MR-Guided Adaptive Radiotherapy (SMART) in Borderline Resectable and Locally Advanced Pancreatic Cancer: A Prospective Study. Biomedicines, 13(10), 2390. https://doi.org/10.3390/biomedicines13102390