Novel Therapeutics for Type 2 Diabetes Mellitus—A Look at the Past Decade and a Glimpse into the Future
Abstract
1. Introduction
2. Materials and Methods
3. SGLT2 Inhibitors
3.1. Effects of SGLT2 Inhibitors on Vascular Function
3.2. Effects of SGLT2 Inhibitors on Mechanisms in Atherosclerosis
- SGLT2 inhibitors reduce vascular inflammation.
- 2.
- SGLT2 inhibitors attenuate oxidative stress and atherosclerosis
- 3.
- SGLT2 inhibitors reduce thrombosis
3.3. SGLT2 Inhibitors and Heart Failure
- Clinical trials and cardiac markers
3.4. SGLT2 Inhibitors and the Kidneys
- Clinical trials focusing on renal outcomes
- 2.
- Mechanisms of SGLT2 inhibitors in renal protection.
3.5. Adverse Effects Associated with SGLT2 Inhibitors
3.6. Dual SGLT1 and SGLT2 Inhibitors
4. GLP-1 Receptor Agonist (GLP-1 RA)
4.1. Effects of GLP-1 RA on Endothelial Function and Arterial Stiffness
4.2. Mechanisms of Cardiovascular Protection by GLP-1 RA
- Inflammation
- 2.
- Oxidative stress
- 3.
- Thrombosis
4.3. Effects of GLP-1 RA on Heart Failure
4.4. Effects of GLP-1 RA on Renal Function
4.5. Adverse Effects Associated with GLP-1 RA
4.6. Combination Agents with GLP-1
- GLP-1 + amylin analogue
- 2.
- GLP-1 + GIP receptor agonist (tirzepatide)
- 3.
- GLP-1 + glucagon receptor agonist
- 4.
- GLP-1-glucagon agonism and potential cardiorenal benefits
- 5.
- Triple GLP-1 + GIP + glucagon receptor agonist (retratrutide)
5. Novel Glucose-Lowering Agents in Early-Phase Trials
- Glimin
- 2.
- Dual peroxisome proliferator-activated receptor (PPARα/γ) agonist
- 3.
- Glucokinase activator
- 4.
- G-protein coupled receptor 40 (GPR40) agonist
6. Future Directions and Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Chee, Y.J.; Dalan, R. Novel Therapeutics for Type 2 Diabetes Mellitus—A Look at the Past Decade and a Glimpse into the Future. Biomedicines 2024, 12, 1386. https://doi.org/10.3390/biomedicines12071386
Chee YJ, Dalan R. Novel Therapeutics for Type 2 Diabetes Mellitus—A Look at the Past Decade and a Glimpse into the Future. Biomedicines. 2024; 12(7):1386. https://doi.org/10.3390/biomedicines12071386
Chicago/Turabian StyleChee, Ying Jie, and Rinkoo Dalan. 2024. "Novel Therapeutics for Type 2 Diabetes Mellitus—A Look at the Past Decade and a Glimpse into the Future" Biomedicines 12, no. 7: 1386. https://doi.org/10.3390/biomedicines12071386
APA StyleChee, Y. J., & Dalan, R. (2024). Novel Therapeutics for Type 2 Diabetes Mellitus—A Look at the Past Decade and a Glimpse into the Future. Biomedicines, 12(7), 1386. https://doi.org/10.3390/biomedicines12071386