Coenzyme Q10-Loaded Albumin Nanoparticles Protect against Redox Imbalance and Inflammatory, Apoptotic, and Histopathological Alterations in Mercuric Chloride-Induced Hepatorenal Toxicity in Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Preparation and Characterization of CoQ10NPs
2.3. Animals, Treatment Protocol, and Sampling
2.4. Serum Liver and Renal Markers
2.5. Hepatorenal Oxidative/Antioxidant Status
2.6. Hepatorenal Inflammatory and Fibrotic Mediators
2.7. Hepatorenal Apoptotic Markers
2.8. Histopathology of Liver and Kidney
2.9. Statistical Evaluation
3. Results
3.1. Coenzyme Q10-Loaded Albumin Nanoparticle (CoQ10NP) Characterization
3.2. Effect of CoQ10NPs on Serum Hepatic and Renal Markers upon HgCl2 Exposure
3.3. Effect of CoQ10NPs on Hepatorenal Oxidative Stress Markers upon HgCl2 Exposure
3.4. Effect of CoQ10NPs on Hepatorenal Inflammatory Mediators upon HgCl2 Exposure
3.5. Effect of CoQ10NPs on Hepatic Alpha-Smooth Muscle Actin (α-SMA) Level upon HgCl2 Exposure
3.6. Effect of CoQ10NPs on Hepatorenal Apoptotic Markers upon HgCl2 Exposure
3.7. Effect of CoQ10NPs on Histological Alterations in Liver and Kidney upon HgCl2 Exposure
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ramadan, S.S.; El Zaiat, F.A.; Habashy, E.A.; Montaser, M.M.; Hassan, H.E.; Tharwat, S.S.; El-khadragy, M.; Abdel Moneim, A.E.; Elshopakey, G.E.; Akabawy, A.M.A. Coenzyme Q10-Loaded Albumin Nanoparticles Protect against Redox Imbalance and Inflammatory, Apoptotic, and Histopathological Alterations in Mercuric Chloride-Induced Hepatorenal Toxicity in Rats. Biomedicines 2023, 11, 3054. https://doi.org/10.3390/biomedicines11113054
Ramadan SS, El Zaiat FA, Habashy EA, Montaser MM, Hassan HE, Tharwat SS, El-khadragy M, Abdel Moneim AE, Elshopakey GE, Akabawy AMA. Coenzyme Q10-Loaded Albumin Nanoparticles Protect against Redox Imbalance and Inflammatory, Apoptotic, and Histopathological Alterations in Mercuric Chloride-Induced Hepatorenal Toxicity in Rats. Biomedicines. 2023; 11(11):3054. https://doi.org/10.3390/biomedicines11113054
Chicago/Turabian StyleRamadan, Shimaa S., Farah A. El Zaiat, Engy A. Habashy, Mostafa M. Montaser, Habeba E. Hassan, Shahinaz S. Tharwat, Manal El-khadragy, Ahmed E. Abdel Moneim, Gehad E. Elshopakey, and Ahmed M. A. Akabawy. 2023. "Coenzyme Q10-Loaded Albumin Nanoparticles Protect against Redox Imbalance and Inflammatory, Apoptotic, and Histopathological Alterations in Mercuric Chloride-Induced Hepatorenal Toxicity in Rats" Biomedicines 11, no. 11: 3054. https://doi.org/10.3390/biomedicines11113054