Next Article in Journal
Bioinformatics: From NGS Data to Biological Complexity in Variant Detection and Oncological Clinical Practice
Next Article in Special Issue
Quantitative Sensory Testing in Late-Onset ATTRv Presymptomatic Subjects: A Single Center Experience
Previous Article in Journal
Membranolytic Mechanism of Amphiphilic Antimicrobial β-Stranded [KL]n Peptides
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 10
Issue 9
10.3390/biomedicines10092073
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis

by
Chiara Cambieri
1,
Laura Libonati
1,
Federica Moret
1,
Giorgio Tartaglia
1,
Matteo Garibaldi
2,
Cristina Chimenti
3,4,
Maurizio Inghilleri
1 and
Marco Ceccanti
1,*
1
Center for Rare Neuromuscular Diseases, Department of Human Neuroscience, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy
2
Neuromuscular and Rare Disease Center, Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy
3
Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Sapienza University, 00185 Rome, Italy
4
Cellular and Molecular Cardiology Lab, IRCCS Lazzaro Spallanzani, 00149 Rome, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(9), 2073; https://doi.org/10.3390/biomedicines10092073
Submission received: 11 July 2022 / Revised: 20 August 2022 / Accepted: 23 August 2022 / Published: 24 August 2022
(This article belongs to the Special Issue Amyloidosis: Current Status on Diagnosis, Management and Therapeutic Strategies)
Browse Figure
Versions Notes

Abstract

Background: Transthyretin-mediated amyloidosis (ATTR) is a rare multisystemic disease involving the peripheral nervous system and heart. Autonomic and small fiber involvement is one of the hallmarks of ATTR, and many tools have been proposed to assess this aspect. Aim: The aim of this study was to investigate cutaneous and mixed nerve silent periods (CSP and MnSP) as instruments for small fiber assessment. Methods: A total of 21 ATTR patients, 20 healthy controls, and 18 asymptomatic carriers underwent a sensory conduction study from the right sural and non-dominant ulnar nerves. A motor conduction study from the right deep peroneal and non-dominant ulnar nerves, with their F waves, CSPs, and MnSPs, was performed. Results: The amplitudes of the sural and ulnar sensory nerves and of the peroneal and ulnar motor nerves were reduced in ATTR patients compared to the other groups. F waves from the ulnar and peroneal nerves showed no differences between the three groups. The CSP and MnSP latency, but not amplitude, were increased in both the ulnar and peroneal nerves of ATTR patients. Conclusions: ATTR patients showed axonal involvement of large sensory and motor nerve fibers and demyelinating features of small sensory fibers.
Keywords: transthyretin-mediated amyloidosis; cutaneous silent period; mixed nerve silent period; neurophysiology transthyretin-mediated amyloidosis; cutaneous silent period; mixed nerve silent period; neurophysiology

Share and Cite

MDPI and ACS Style

Cambieri, C.; Libonati, L.; Moret, F.; Tartaglia, G.; Garibaldi, M.; Chimenti, C.; Inghilleri, M.; Ceccanti, M. The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis. Biomedicines 2022, 10, 2073. https://doi.org/10.3390/biomedicines10092073

AMA Style

Cambieri C, Libonati L, Moret F, Tartaglia G, Garibaldi M, Chimenti C, Inghilleri M, Ceccanti M. The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis. Biomedicines. 2022; 10(9):2073. https://doi.org/10.3390/biomedicines10092073

Chicago/Turabian Style

Cambieri, Chiara, Laura Libonati, Federica Moret, Giorgio Tartaglia, Matteo Garibaldi, Cristina Chimenti, Maurizio Inghilleri, and Marco Ceccanti. 2022. "The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis" Biomedicines 10, no. 9: 2073. https://doi.org/10.3390/biomedicines10092073

APA Style

Cambieri, C., Libonati, L., Moret, F., Tartaglia, G., Garibaldi, M., Chimenti, C., Inghilleri, M., & Ceccanti, M. (2022). The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis. Biomedicines, 10(9), 2073. https://doi.org/10.3390/biomedicines10092073

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop