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Article

Administration Routes as Modulators of the Intrahepatic Distribution and Anti-Anemic Activity of Salicylic Acid/Fe3O4 Nanoparticles

1
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Morphology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 011061 Bucharest, Romania
5
Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Li Li, Run Zhang and Zhi Ping Xu
Biomedicines 2022, 10(5), 1213; https://doi.org/10.3390/biomedicines10051213
Received: 30 April 2022 / Revised: 19 May 2022 / Accepted: 21 May 2022 / Published: 23 May 2022
(This article belongs to the Special Issue Advances in Nanomedicine for Disease Treatment and Diagnosis)
The liver is a key organ in the pharmacokinetics of iron oxide nanoparticles (IONPs). This paper examined how the intravenous (IV) or intragastric (IG) route of administration influenced the intrahepatic distribution or therapeutic effects of IONPs. Wistar rats, some with bleeding-induced anemia, and iron oxide nanoparticles functionalized with salicylic acid (SaIONPs), with an average hydrodynamic diameter of 73 nm, compatible with rat sinusoid fenestrations, were used in this study. Light microscopy and multispectral camera analysis of Prussian blue labeled SaIONPs allowed mapping of intrahepatic nanoparticle deposits and revealed intrahepatic distribution patterns specific to each route of administration: loading of Kupffer cells and periportal hepatocytes when the IV route was used and predominant loading of hepatocytes when the IG route was used. Reducing the time to return to baseline values for hemoglobin (HGB) in rats with bleeding-induced anemia with IV or IG therapy has proven the therapeutic potential of SaIONPs in such anemias. The long-term follow-up showed that IV therapy resulted in higher HGB values. Proper use of the administration routes may modulate intrahepatic distribution and therapeutic effects of nanoparticles. These results may be beneficial in theragnosis of liver disease. View Full-Text
Keywords: iron oxide nanoparticles; salicylic acid; administration routes; bleeding-induced anemia; liver zonation iron oxide nanoparticles; salicylic acid; administration routes; bleeding-induced anemia; liver zonation
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MDPI and ACS Style

Mîndrilă, B.; Buteică, S.-A.; Mîndrilă, I.; Mihaiescu, D.-E.; Mănescu, M.-D.; Rogoveanu, I. Administration Routes as Modulators of the Intrahepatic Distribution and Anti-Anemic Activity of Salicylic Acid/Fe3O4 Nanoparticles. Biomedicines 2022, 10, 1213. https://doi.org/10.3390/biomedicines10051213

AMA Style

Mîndrilă B, Buteică S-A, Mîndrilă I, Mihaiescu D-E, Mănescu M-D, Rogoveanu I. Administration Routes as Modulators of the Intrahepatic Distribution and Anti-Anemic Activity of Salicylic Acid/Fe3O4 Nanoparticles. Biomedicines. 2022; 10(5):1213. https://doi.org/10.3390/biomedicines10051213

Chicago/Turabian Style

Mîndrilă, Bogdan, Sandra-Alice Buteică, Ion Mîndrilă, Dan-Eduard Mihaiescu, Marina-Daniela Mănescu, and Ion Rogoveanu. 2022. "Administration Routes as Modulators of the Intrahepatic Distribution and Anti-Anemic Activity of Salicylic Acid/Fe3O4 Nanoparticles" Biomedicines 10, no. 5: 1213. https://doi.org/10.3390/biomedicines10051213

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