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Article

The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes

1
Sistema BioTech LLC, 109235 Moscow, Russia
2
Clinical Laboratory, N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine, 129010 Moscow, Russia
3
Clinical Laboratory, Moscow City Clinical Hospital #40, 129301 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Pasquale Ambrosino
Biomedicines 2022, 10(3), 549; https://doi.org/10.3390/biomedicines10030549
Received: 10 January 2022 / Revised: 11 February 2022 / Accepted: 16 February 2022 / Published: 25 February 2022
The aim of this study was to identify single nucleotide variants in genes associated with susceptibility to or severe outcomes of COVID-19. A total of 319 genomic DNA samples from patients with varying degrees of disease severity and 78 control DNA samples from people who had regular or prolonged contact with patients with COVID-19 but did not have clinical manifestations and/or antibodies to SARS-CoV-2. Seven SNPs were identified that were statistically associated with disease risk or severe course, rs1799864 in the CCR2 gene (OR = 2.21), rs1990760 in the IFIH1 gene (OR = 2.41), rs1800629 in the TNF gene (OR = 1.98), rs75603675 in the TMPRSS2 gene (OR = 1.86), rs7842 in the C3AR1 gene (OR = 2.08), rs179008 in the gene TLR7 (OR = 1.85), rs324011 in the C3AR1 gene (OR = 2.08), rs179008 in the TLR7 gene (OR = 1.85), and rs324011 in the STAT6 gene (OR = 1.84), as well as two variants associated with protection from COVID-19, rs744166 in the STAT3 gene (OR = 0.36) and rs1898830 in the TLR2 gene (OR = 0.47). The genotype in the region of these markers can be the criterion of the therapeutic approach for patients with COVID-19. View Full-Text
Keywords: COVID-19; single nucleotide polymorphism; genetic variant; SARS-CoV-2; heaviness; susceptibility; antiviral immunity COVID-19; single nucleotide polymorphism; genetic variant; SARS-CoV-2; heaviness; susceptibility; antiviral immunity
MDPI and ACS Style

Minashkin, M.M.; Grigortsevich, N.Y.; Kamaeva, A.S.; Barzanova, V.V.; Traspov, A.A.; Godkov, M.A.; Ageev, F.A.; Petrikov, S.S.; Pozdnyakova, N.V. The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes. Biomedicines 2022, 10, 549. https://doi.org/10.3390/biomedicines10030549

AMA Style

Minashkin MM, Grigortsevich NY, Kamaeva AS, Barzanova VV, Traspov AA, Godkov MA, Ageev FA, Petrikov SS, Pozdnyakova NV. The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes. Biomedicines. 2022; 10(3):549. https://doi.org/10.3390/biomedicines10030549

Chicago/Turabian Style

Minashkin, Mikhail M., Nataliya Y. Grigortsevich, Anna S. Kamaeva, Valeriya V. Barzanova, Alexey A. Traspov, Mikhail A. Godkov, Farkhad A. Ageev, Sergey S. Petrikov, and Nataliya V. Pozdnyakova. 2022. "The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes" Biomedicines 10, no. 3: 549. https://doi.org/10.3390/biomedicines10030549

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