Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification
Abstract: Background
1. Introduction
2. Materials and Methods
2.1. Ethics
2.2. Study Design
2.3. Data Collection
2.4. Image Grading and Analysis
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total patients screened (nscreen) | 1990 (3980 eyes) |
Patients identified as suitable (npatient) | 268 (536 eyes) |
Patients removed due to fibrovascular scarring or poor image quality (ndropped) | 77 (154 eyes) (29%) |
Patients included (npatient) | 191 (382 eyes) (71%) |
Eyes included (1 per patient) (n) | 191 eyes |
Localization OD/OS | 97 (51%)/94 (49%) |
Gender female/male | 117 (61%)/74 (39%) |
Age mean (years) ± SD | 77.9 ± 7.8 |
BCVA mean ± SD | 56.6 ± 21.2 ETDRS letters |
Glaucoma | 22 (12%) |
Arterial hypertension | 92 (48%) |
Diabetes mellitus | 17 (9%) |
Total | MNV 1 | MNV 2 | MNV 3 | MNV Mixed 1/2 | |
---|---|---|---|---|---|
Eyes included (n) | 191 (100%) | 80 (42%) | 23 (12%) | 49 (26%) | 39 (20%) |
Soft drusen only | 38 (20%) | 34 (43%) | 0 (0%) | 1 (2%) | 3 (8%) |
Predominant soft drusen | 43 (23%) | 32 (40%) | 1 (4%) | 4 (8%) | 6 (15%) |
SDD only | 39 (20%) | 3 (4%) | 14 (61%) | 13 (27%) | 9 (23%) |
Predominant SDD | 71 (37%) | 11 (14%) | 8 (35%) | 31 (63%) | 21 (54%) |
aOR | 95% CI | p | |
---|---|---|---|
MNV 1 | |||
Soft drusen only | 19.0008 | 7.0019; 66.9073 | <0.0001 |
Predominant soft drusen | 27.9873 | 13.0180; 64.5909 | <0.0001 |
SDD only | 0.0806 | 0.01867; 0.2395 | <0.0001 |
Predominant SDD | 0.0357 | 0.0155; 0.0768 | <0.0001 |
MNV 2 | |||
Soft drusen only | n.s. | n.s. | 0.8700 |
Predominant soft drusen | 0.0427 | 0.0023; 0.2165 | 0.0025 |
SDD only | 9.2945 | 3.6536; 24.9841 | <0.0001 |
Predominant SDD | 23.4453 | 4.6190; 429.4434 | 0.0025 |
MNV 3 | |||
Soft drusen only | 0.0661 | 0.0037; 0.3243 | 0.00853 |
Predominant soft drusen | 0.1145 | 0.0376; 0.2849 | <0.0001 |
SDD only | n.s. | n.s. | 0.3198 |
Predominant SDD | 8.7374 | 0.5105; 26.5916 | <0.0001 |
MNV 1/2 mixed | |||
Soft drusen only | 0.2816 | 0.0650; 0.8484 | 0.0455 |
Predominant soft drusen | 0.3284 | 0.1364; 0.7268 | 0.0084 |
SDD only | n.s. | n.s. | 0.6690 |
Predominant SDD | 0.3284 | 0.1364; 0.7268 | 0.0084 |
Coeff. | 95% CI | p | |
---|---|---|---|
MNV type vs. Glaucoma | 0.0757 | 0.0000; 0.0966 | 0.9063 |
MNV type vs. Hypertension | 0.1153 | 0.0000; 0.1677 | 0.5471 |
MNV type vs. Diabetes | 0.0726 | 0.0000; 0.0887 | 0.9221 |
Druse type vs. Glaucoma | 0.0788 | 0.0000; 0.1048 | 0.8828 |
Druse type vs. Hypertension | 0.1091 | 0.0000; 0.1321 | 0.6556 |
Druse type vs. Diabetes | 0.1269 | 0.0000; 0.1591 | 0.4171 |
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Muth, D.R.; Toro, M.D.; Bajka, A.; Jonak, K.; Rieder, R.; Kohler, M.M.; Gunzinger, J.M.; Souied, E.H.; Engelbert, M.; Freund, K.B.; et al. Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification. Biomedicines 2022, 10, 2370. https://doi.org/10.3390/biomedicines10102370
Muth DR, Toro MD, Bajka A, Jonak K, Rieder R, Kohler MM, Gunzinger JM, Souied EH, Engelbert M, Freund KB, et al. Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification. Biomedicines. 2022; 10(10):2370. https://doi.org/10.3390/biomedicines10102370
Chicago/Turabian StyleMuth, Daniel Rudolf, Mario Damiano Toro, Anahita Bajka, Kamil Jonak, Roman Rieder, Myrtha Magdalena Kohler, Jeanne Martine Gunzinger, Eric H. Souied, Michael Engelbert, K. Bailey Freund, and et al. 2022. "Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification" Biomedicines 10, no. 10: 2370. https://doi.org/10.3390/biomedicines10102370
APA StyleMuth, D. R., Toro, M. D., Bajka, A., Jonak, K., Rieder, R., Kohler, M. M., Gunzinger, J. M., Souied, E. H., Engelbert, M., Freund, K. B., & Zweifel, S. A. (2022). Correlation between Macular Neovascularization (MNV) Type and Druse Type in Neovascular Age-Related Macular Degeneration (AMD) Based on the CONAN Classification. Biomedicines, 10(10), 2370. https://doi.org/10.3390/biomedicines10102370