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• Winters, NI.
• Bader, DM.
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• Bader, DM.

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J. Dev. Biol. 2013, 1(2), 64-81; doi:10.3390/jdb1020064

Review

Development of the Serosal Mesothelium

Nichelle I. Winters and David M. Bader *

Department of Medicine, Vanderbilt University, 2220 Pierce Ave Nashville, TN 37232, USA

* Author to whom correspondence should be addressed.

Received: 3 May 2013; in revised form: 13 June 2013 / Accepted: 19 June 2013 / Published: 26 June 2013

(This article belongs to the Special Issue Epicardial Development and Cardiovascular Disease)

Download PDF Full-Text [1068 KB, uploaded 26 June 2013 09:46 CEST]

Abstract: Mesothelia in the adult vertebrate are the simple squamous epithelia covering all coelomic organs and body cavities. Until recently, analysis of the generation and differentiative potential of mesothelia in organogenesis has largely focused on development of visceral mesothelium of the heart; the epicardium and its progenitor, the proepicardium. Here, we review emerging data on the development and differentiation of serosal mesothelium, the covering of the gastrointestinal tract. This literature demonstrates that serosal mesothelium is generated through a completely different mechanism than that seen in the heart suggesting that commitment of progenitors to this cell lineage does not follow a common pathway. The differentiative potential of serosal mesothelium is also discussed in comparison to that observed for progeny of the proepicardium/epicardium. In our review of the literature, we point out gaps in our understanding of serosal mesothelial development and that of mesothelial development as a whole.

Keywords: mesothelium; proepicardium; epicardium; intestine; heart

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