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Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferi

Department of Microbiology and Immunology, New York Medical College, School of Medicine, Valhalla, NY 10595, USA
Author to whom correspondence should be addressed.
Academic Editor: Zvi Loewy
Microarrays 2016, 5(2), 9;
Received: 7 March 2016 / Revised: 28 March 2016 / Accepted: 11 April 2016 / Published: 16 April 2016
(This article belongs to the Special Issue Microfluidics Technology)
PDF [619 KB, uploaded 16 April 2016]


Borrelia burgdorferi, the spirochetal agent of Lyme disease, is maintained in nature in a cycle involving a tick vector and a mammalian host. Adaptation to the diverse conditions of temperature, pH, oxygen tension and nutrient availability in these two environments requires the precise orchestration of gene expression. Over 25 microarray analyses relating to B. burgdorferi genomics and transcriptomics have been published. The majority of these studies has explored the global transcriptome under a variety of conditions and has contributed substantially to the current understanding of B. burgdorferi transcriptional regulation. In this review, we present a summary of these studies with particular focus on those that helped define the roles of transcriptional regulators in modulating gene expression in the tick and mammalian milieus. By performing comparative analysis of results derived from the published microarray expression profiling studies, we identified composite gene lists comprising differentially expressed genes in these two environments. Further, we explored the overlap between the regulatory circuits that function during the tick and mammalian phases of the enzootic cycle. Taken together, the data indicate that there is interplay among the distinct signaling pathways that function in feeding ticks and during adaptation to growth in the mammal. View Full-Text
Keywords: microarray; Borrelia burgdorferi; transcriptome; Lyme disease; transcriptional regulators microarray; Borrelia burgdorferi; transcriptome; Lyme disease; transcriptional regulators

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Iyer, R.; Schwartz, I. Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferi. Microarrays 2016, 5, 9.

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