Special Issue "Antioxidants 2012"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 November 2012)
Dr. Dejian Huang
Food Science & Technology Programme, c/o Department of Chemistry, 3 Science Drive 3, Faculty of Science, National University of Singapore, 117543 Singapore
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Fax: +65 6775 7895
Interests: fabrication of quantum dots; transition metal complex; polyphenolic compounds; antioxidant; pro-oxidant activity
Mounting evidence suggests that oxidative stress is the causative factor for chronic diseases including cardiovascular diseases, cancer, diabetes, neurodegenerative diseases and ageing. Preventing these chronic diseases through antioxidants (or radical scavengers) has been a very attractive idea as evidenced by the large amount of scholarly articles published. As a result, the notion that dietary antioxidant are beneficial to our health is widely accepted in general public. Scientifically, the action mechanisms of antioxidant are much more complex and remain to be a hotly pursued research field. Antioxidants may work as oxidase (e.g. lipoxygenases and cyclooxygenase) inhibitor, transition metal chelators (preventing Fenton reaction), and scavengers of wide range of biologically relevant reactive oxygen species including superoxide, peroxyl radicals, hypochlorite, peroxynitrite and nitrogen dioxide, and singlet oxygen. In this special issue on “antioxidants” the contributions may cover chemical, cell line, and in vivo protocols or methods in evaluation of antioxidant activity against oxidants or oxidative stress; chemical synthesis of novel antioxidant compounds and their activity and action mechanisms; extraction, isolation and structural characterization of dietary antioxidants from natural resources; activity and mechanisms of antioxidants in chemical, food, and biological models; replacement of synthetic radical scavengers (e.g. BHT) by naturally occurring antioxidants; digestion, absorption, and metabolism of dietary antioxidants in animal model and human study; efficacy of antioxidants in mitigating oxidative stress status in human clinical trials.
Dr. Dejian Huang
• radical scavengers
• analytical methods
• structure elucidation
• mechanism of action
• oxidative stress
• natural products