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Molecules 2012, 17(11), 12734-12745; doi:10.3390/molecules171112734
Article

Preparation, Characterization and Efficacy Evaluation of Synthetic Biocompatible Polymers Linking Natural Antioxidants

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Received: 13 July 2012; in revised form: 18 September 2012 / Accepted: 22 October 2012 / Published: 26 October 2012
(This article belongs to the Special Issue Antioxidants 2012)
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Abstract: The purpose of this work was the synthesis, characterization and efficacy evaluation of new biocompatible antioxidant polymers linking trans-ferulic acid or a-lipoic acid. In particular, ferulic or lipoic acid were introduced in the preformed polymeric backbone. The new antioxidant biopolymers were characterized by Fourier transform infrared spectroscopy and gel permeation chromatography. The degree of functionalization (moles of antioxidant per gram of polymer) was determined by the Gaur-Gupta method for free amino group determination and by the Folin method for the phenolic groups. Their ability to inhibit lipid peroxidation were estimated in rat liver microsomal membranes induced in vitro by tert-BOOH (tert-butyl hydroperoxide), as a source of free radicals. The DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging effect was also evaluated. The obtained systems, with different solubility, showed strong antioxidant and antiradical activities, suggesting potential use as packaging materials for foods, cosmetics, pharmaceuticals and personal care products. Moreover, the cytotoxicity of the synthesized polymers was also evaluated on Caco-2 cell cultures in order to verify their biocompatibility when exposed to an absorptive epithelial cell line.
Keywords: antioxidants; biocompatible polymers; lipid peroxidation; trans-ferulic acid; a-lipoic acid antioxidants; biocompatible polymers; lipid peroxidation; trans-ferulic acid; a-lipoic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Trombino, S.; Cassano, R.; Ferrarelli, T.; Leta, S.; Puoci, F.; Picci, N. Preparation, Characterization and Efficacy Evaluation of Synthetic Biocompatible Polymers Linking Natural Antioxidants. Molecules 2012, 17, 12734-12745.

AMA Style

Trombino S, Cassano R, Ferrarelli T, Leta S, Puoci F, Picci N. Preparation, Characterization and Efficacy Evaluation of Synthetic Biocompatible Polymers Linking Natural Antioxidants. Molecules. 2012; 17(11):12734-12745.

Chicago/Turabian Style

Trombino, Sonia; Cassano, Roberta; Ferrarelli, Teresa; Leta, Sonia; Puoci, Francesco; Picci, Nevio. 2012. "Preparation, Characterization and Efficacy Evaluation of Synthetic Biocompatible Polymers Linking Natural Antioxidants." Molecules 17, no. 11: 12734-12745.


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