Molecules 2012, 17(10), 11484-11494; doi:10.3390/molecules171011484
Article

The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

Kang In Choe, Joo Hee Kwon, Kwan Hee Park, Myeong Hwan Oh, Manh Heun Kim, Han Hyuk Kim, Su Hyun Cho, Eun Kyung Chung, Sung Yi Ha and Min Won Lee* email
College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea
* Author to whom correspondence should be addressed.
Received: 4 July 2012; in revised form: 28 August 2012 / Accepted: 21 September 2012 / Published: 27 September 2012
(This article belongs to the Special Issue Antioxidants 2012)
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Abstract: Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
Keywords: Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC

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MDPI and ACS Style

Choe, K.I.; Kwon, J.H.; Park, K.H.; Oh, M.H.; Kim, M.H.; Kim, H.H.; Cho, S.H.; Chung, E.K.; Ha, S.Y.; Lee, M.W. The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR. Molecules 2012, 17, 11484-11494.

AMA Style

Choe KI, Kwon JH, Park KH, Oh MH, Kim MH, Kim HH, Cho SH, Chung EK, Ha SY, Lee MW. The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR. Molecules. 2012; 17(10):11484-11494.

Chicago/Turabian Style

Choe, Kang In; Kwon, Joo Hee; Park, Kwan Hee; Oh, Myeong Hwan; Kim, Manh Heun; Kim, Han Hyuk; Cho, Su Hyun; Chung, Eun Kyung; Ha, Sung Yi; Lee, Min Won. 2012. "The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR." Molecules 17, no. 10: 11484-11494.

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