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Molecules 2012, 17(12), 14637-14650; doi:10.3390/molecules171214637

Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada
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Received: 25 October 2012 / Revised: 9 November 2012 / Accepted: 5 December 2012 / Published: 10 December 2012
(This article belongs to the Special Issue Antioxidants 2012)
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Abstract

Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.
Keywords: CAPE; caffeic acid; 3-(3,4-dihydroxyphenyl) propanoic acid esters; 2-(3,4-dihydroxyphenyl) acetic acid esters; 3,4-dihydroxybenzoic acid esters; antioxidant CAPE; caffeic acid; 3-(3,4-dihydroxyphenyl) propanoic acid esters; 2-(3,4-dihydroxyphenyl) acetic acid esters; 3,4-dihydroxybenzoic acid esters; antioxidant
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MDPI and ACS Style

LeBlanc, L.M.; Paré, A.F.; Jean-François, J.; Hébert, M.J.G.; Surette, M.E.; Touaibia, M. Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc. Molecules 2012, 17, 14637-14650.

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