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Molecules 2012, 17(12), 14637-14650; doi:10.3390/molecules171214637
Article

Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc

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Received: 25 October 2012; in revised form: 9 November 2012 / Accepted: 5 December 2012 / Published: 10 December 2012
(This article belongs to the Special Issue Antioxidants 2012)
Download PDF [239 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.
Keywords: CAPE; caffeic acid; 3-(3,4-dihydroxyphenyl) propanoic acid esters; 2-(3,4-dihydroxyphenyl) acetic acid esters; 3,4-dihydroxybenzoic acid esters; antioxidant CAPE; caffeic acid; 3-(3,4-dihydroxyphenyl) propanoic acid esters; 2-(3,4-dihydroxyphenyl) acetic acid esters; 3,4-dihydroxybenzoic acid esters; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

LeBlanc, L.M.; Paré, A.F.; Jean-François, J.; Hébert, M.J.G.; Surette, M.E.; Touaibia, M. Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc. Molecules 2012, 17, 14637-14650.

AMA Style

LeBlanc LM, Paré AF, Jean-François J, Hébert MJG, Surette ME, Touaibia M. Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc. Molecules. 2012; 17(12):14637-14650.

Chicago/Turabian Style

LeBlanc, Luc M.; Paré, Aurélie F.; Jean-François, Jacques; Hébert, Martin J.G.; Surette, Marc E.; Touaibia, Mohamed. 2012. "Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analoguesc." Molecules 17, no. 12: 14637-14650.


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