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Molecules 2012, 17(10), 11816-11825; doi:10.3390/molecules171011816

Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity

2,*  and 1,*
Received: 26 July 2012 / Revised: 28 September 2012 / Accepted: 30 September 2012 / Published: 9 October 2012
(This article belongs to the Special Issue Antioxidants 2012)
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Skin pigmentation disorders typically involve an overproduction or uneven distribution of melanin, which results in skin spots. Resveratrol can inhibit tyrosinase, the active enzyme in the synthesis of melanin, but it does not inhibit the synthesis of melanin to an extent that enables its use alone as a skin whitening agent in pharmaceutical formulations, so its use as a coadjuvant in treatment of hyperpigmentation is suggested. Six resveratrol analogs were tested for tyrosinase inhibitory activity in vitro. Among the analogs tested, compound D was the most powerful tyrosinase inhibitor (IC50 = 28.66 µg/mL), two times more active than resveratrol (IC50 = 57.05 µg/mL), followed by the analogs A, E, B, F and C, respectively. This demonstrated that the hydroxylation at C4' on the phenolic ring was the molecular modification with most importance for the observed activity.
Keywords: chemical synthesis; mushroom tyrosinase activity; structure-activity; tyrosinase; activity in vitro chemical synthesis; mushroom tyrosinase activity; structure-activity; tyrosinase; activity in vitro
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zimmermann Franco, D.C.; Gonçalves de Carvalho, G.S.; Rocha, P.R.; da Silva Teixeira, R.; da Silva, A.D.; Barbosa Raposo, N.R. Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity. Molecules 2012, 17, 11816-11825.

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