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Molecules 2012, 17(10), 11391-11420; doi:10.3390/molecules171011391
Review

Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease

, , , ,  and *
Received: 30 August 2012; in revised form: 12 September 2012 / Accepted: 21 September 2012 / Published: 26 September 2012
(This article belongs to the Special Issue Antioxidants 2012)
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Abstract: Parkinson’s disease (PD) is a complex multifactorial disease marked by extensive neuropathology in the brain with selective yet prominent and progressive loss of mid-brain dopaminergic neurons. The etiological factors involved in the development of PD are still elusive, but oxidative stress arising when reactive oxygen species (ROS) exceed amounts required for normal redox signaling is considered one of the major factors. ROS cause oxidative damage to proteins, lipids, and DNA and are one of the most prominent factors related to neurodegeneration. Pre-clinical and clinical studies clearly demonstrate the effectiveness of oxidative stress in the pathogenesis of PD. Therefore, regulation of redox signaling and inhibiting excess ROS would contribute greatly not only to extend longevity but also to ameliorate the progression of dopaminergic cell death seen in patients with PD. Several herbal products are beneficial for maintaining nerve cell function and for treating various neurodegenerative disorders by reducing oxidative stress. Here, we summarize the recent knowledge concerning promising herbs that have shown significant beneficial effects based on regulation of redox status and ROS inhibition in toxin-induced PD models.
Keywords: Parkinson’s disease; oxidative stress; redox signaling; antioxidant herbs; reactive oxygen species; 6-hydroxydopamine; substantia nigra Parkinson’s disease; oxidative stress; redox signaling; antioxidant herbs; reactive oxygen species; 6-hydroxydopamine; substantia nigra
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Koppula, S.; Kumar, H.; More, S.V.; Lim, H.-W.; Hong, S.-M.; Choi, D.-K. Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease. Molecules 2012, 17, 11391-11420.

AMA Style

Koppula S, Kumar H, More SV, Lim H-W, Hong S-M, Choi D-K. Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease. Molecules. 2012; 17(10):11391-11420.

Chicago/Turabian Style

Koppula, Sushruta; Kumar, Hemant; More, Sandeep Vasant; Lim, Hyung-Woo; Hong, Soon-Min; Choi, Dong-Kug. 2012. "Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease." Molecules 17, no. 10: 11391-11420.


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