Special Issue "Cancer Stem Cells"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 November 2010)

Special Issue Editors

Guest Editor
Prof. Dr. Albert D. Donnenberg
1 Medicine and Infectious Diseases and Microbiology Director, UPCI Cytometry Laboratory, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
2 Laboratory Director, UPMC Hematopoietic Stem Cell Laboratory, 5117 Centre Ave., Pittsburgh, PA 15213, USA
3 Deputy Director, UPCI Hematopoietic Stem Cell Transplantation Program, Hillman Cancer Center, 5117 Centre Ave., Suite 4.24c, Pittsburgh, PA 15213, USA
Website: http://www.idm.pitt.edu/directory/bios/donnenberg.asp
E-Mail: donnenbergad@msx.upmc.edu
Phone: +1 412 6233256
Fax: +1 412 6237778
Interests: functional significance of T-cell activation markers; T-cell turnover in SIV infection; role of p-gp in resistance to immunosuppressive agents; immunologic consequences of autologous transplantation in systemic sclerosis; cancer stem cell

Guest Editor
Dr. Vera Svobodova Donnenberg
Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
E-Mail: donnenbergvs@upmc.edu
Interests: P-glycoprotein/ABC-transporters and drug interaction in T lymphocytes and beyond; tumorigenic stem cells; interaction of dormant tumor cells and regenerating tissue; MDR modulation and control by SHH pathway; lung immunology; strengths

Special Issue Information

Dear Colleagues,

Cancer treatment often must deal with the problem of recurrence. This leads to a question: are there specialized cells within a tumor that are relatively resistant to typical therapeutics and which possess the ability to reconstitute the malignancy? Put another way, do tumors contain “stem-like” cells with the properties of resistance and tumor reconstitution? Cancer stem cells (CSCs) have been defined as “cells within a tumor that possess the capacity to self-renew and to cause heterogeneous lineages of cancer cells that comprise the tumor” (see: http://stemcells.nih.gov/info/2006report/2006chapter9.htm). Putative CSCs have been identified for a variety of cancer types, and there are several theories to explain how CSCs develop and how they contribute to disease progression, including metastasis. This topic has profound implications for both the basic science of cancer biology, as well as for more applied studies of clinical and therapeutic relevance. Continued investigation of CSC biology will broaden our understanding of tumor initiation, progression, and metastasis, likely leading to novel preventive and therapeutic approaches against cancer. Therefore, we invite research and review papers in the broad field of cancer stem cells, including, but not limited to, topics relating CSCs to: cancer genetics, tumor biology, metastasis, cell signaling, diet and prevention, and pharmacological and genetic therapeutics. We look forward to your contributions.

Dr. Michael Bordonaro
Dr. Frank Pajonk
Guest Editors

Related Special Issue

Published Papers (25 papers)

Cancers 2011, 3(3), 3525-3556; doi:10.3390/cancers3033525
Received: 9 June 2011; in revised form: 1 August 2011 / Accepted: 8 September 2011 / Published: 13 September 2011
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Cancers 2011, 3(3), 3331-3352; doi:10.3390/cancers3033331
Received: 8 May 2011; in revised form: 27 July 2011 / Accepted: 7 August 2011 / Published: 15 August 2011
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Cancers 2011, 3(2), 2696-2708; doi:10.3390/cancers3022696
Received: 27 April 2011; in revised form: 7 June 2011 / Accepted: 8 June 2011 / Published: 20 June 2011
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Cancers 2011, 3(2), 2655-2666; doi:10.3390/cancers3022655
Received: 4 March 2011; in revised form: 4 May 2011 / Accepted: 31 May 2011 / Published: 10 June 2011
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Cancers 2011, 3(2), 2274-2285; doi:10.3390/cancers3022274
Received: 12 January 2011; in revised form: 12 April 2011 / Accepted: 15 April 2011 / Published: 4 May 2011
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Cancers 2011, 3(2), 2169-2175; doi:10.3390/cancers3022169
Received: 11 February 2011; in revised form: 16 March 2011 / Accepted: 12 April 2011 / Published: 26 April 2011
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Cancers 2011, 3(2), 2050-2079; doi:10.3390/cancers3022050
Received: 3 March 2011; in revised form: 12 April 2011 / Accepted: 13 April 2011 / Published: 19 April 2011
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Cancers 2011, 3(2), 1975-1995; doi:10.3390/cancers3021975
Received: 5 February 2011; in revised form: 19 February 2011 / Accepted: 22 March 2011 / Published: 18 April 2011
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Cancers 2011, 3(2), 1957-1974; doi:10.3390/cancers3021957
Received: 15 December 2010; in revised form: 11 April 2011 / Accepted: 12 April 2011 / Published: 13 April 2011
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Cancers 2011, 3(2), 1777-1797; doi:10.3390/cancers3021777
Received: 22 February 2011; in revised form: 3 March 2011 / Accepted: 22 March 2011 / Published: 30 March 2011
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Cancers 2011, 3(2), 1744-1762; doi:10.3390/cancers3021744
Received: 11 January 2011; in revised form: 25 January 2011 / Accepted: 22 March 2011 / Published: 30 March 2011
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Cancers 2011, 3(2), 1566-1579; doi:10.3390/cancers3021566
Received: 18 February 2011; in revised form: 21 March 2011 / Accepted: 21 March 2011 / Published: 25 March 2011
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Cancers 2011, 3(1), 1467-1479; doi:10.3390/cancers3011467
Received: 30 January 2011; in revised form: 9 February 2011 / Accepted: 9 February 2011 / Published: 22 March 2011
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Cancers 2011, 3(1), 1405-1425; doi:10.3390/cancers3011405
Received: 14 January 2011; in revised form: 17 February 2011 / Accepted: 2 March 2011 / Published: 16 March 2011
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Cancers 2011, 3(1), 1311-1328; doi:10.3390/cancers3011311
Received: 17 February 2011; in revised form: 3 March 2011 / Accepted: 11 March 2011 / Published: 15 March 2011
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Cancers 2011, 3(1), 1232-1252; doi:10.3390/cancers3011232
Received: 7 December 2010; in revised form: 25 January 2011 / Accepted: 24 February 2011 / Published: 10 March 2011
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Cancers 2011, 3(1), 1141-1157; doi:10.3390/cancers3011141
Received: 11 January 2011; in revised form: 21 February 2011 / Accepted: 22 February 2011 / Published: 7 March 2011
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Cancers 2011, 3(1), 1111-1128; doi:10.3390/cancers3011111
Received: 4 January 2011; in revised form: 31 January 2011 / Accepted: 24 February 2011 / Published: 4 March 2011
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Cancers 2011, 3(1), 716-729; doi:10.3390/cancers30100716
Received: 8 December 2010; in revised form: 11 February 2011 / Accepted: 12 February 2011 / Published: 21 February 2011
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Cancers 2011, 3(1), 621-635; doi:10.3390/cancers3010621
Received: 22 November 2010; in revised form: 14 December 2010 / Accepted: 26 January 2011 / Published: 10 February 2011
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Cancers 2011, 3(1), 415-427; doi:10.3390/cancers3010415
Received: 2 December 2010; in revised form: 24 December 2010 / Accepted: 14 January 2011 / Published: 20 January 2011
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Cancers 2011, 3(1), 319-339; doi:10.3390/cancers3010319
Received: 1 December 2010; in revised form: 17 December 2010 / Accepted: 10 January 2011 / Published: 14 January 2011
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Cancers 2011, 3(1), 298-318; doi:10.3390/cancers3010298
Received: 8 December 2011; in revised form: 11 January 2011 / Accepted: 13 January 2011 / Published: 14 January 2011
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Cancers 2011, 3(1), 285-297; doi:10.3390/cancers3010285
Received: 17 November 2010; in revised form: 24 December 2010 / Accepted: 10 January 2011 / Published: 14 January 2011
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Cancers 2010, 2(3), 1576-1596; doi:10.3390/cancers2031576
Received: 23 July 2010; Accepted: 16 August 2010 / Published: 18 August 2010
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Last update: 25 February 2014

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