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• Valkenburg, K
• Graveel, C
• Zylstra-Diegel, C
• Zhong, Z
• Williams, B
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• Valkenburg, K
• Graveel, C
• Zylstra-Diegel, C
• Zhong, Z
• Williams, B
• [+] on PubMed
• Valkenburg, K
• Graveel, C
• Zylstra-Diegel, C
• Zhong, Z
• Williams, B

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Cancers 2011, 3(2), 2050-2079; doi:10.3390/cancers3022050

Review

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells

Kenneth C. Valkenburg, Carrie R. Graveel, Cassandra R. Zylstra-Diegel, Zhendong Zhong and Bart O. Williams*

Van Andel Research Institute, 333 Bostwick Ave. N.E., Grand Rapids, MI 49503, USA

* Author to whom correspondence should be addressed.

Received: 3 March 2011; in revised form: 12 April 2011 / Accepted: 13 April 2011 / Published: 19 April 2011

(This article belongs to the Special Issue Cancer Stem Cells)

Download PDF Full-Text [719 KB, uploaded 19 April 2011 17:16 CEST]

Abstract: The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wnt/β-catenin signaling and how the pathway regulates normal differentiation of stem cells in the intestine, mammary gland, and prostate. We will also discuss how dysregulation of the pathway is associated with putative cancer stem cells and the potential therapeutic implications of regulating Wnt signaling.

Keywords: Wnt; β-catenin; stem cells; cancer stem cells; colon; mammary; prostate; therapeutics

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