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Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
Van Andel Research Institute, 333 Bostwick Ave. N.E., Grand Rapids, MI 49503, USA
* Author to whom correspondence should be addressed.
Received: 3 March 2011; in revised form: 12 April 2011 / Accepted: 13 April 2011 / Published: 19 April 2011
Abstract: The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wnt/β-catenin signaling and how the pathway regulates normal differentiation of stem cells in the intestine, mammary gland, and prostate. We will also discuss how dysregulation of the pathway is associated with putative cancer stem cells and the potential therapeutic implications of regulating Wnt signaling.
Keywords: Wnt; β-catenin; stem cells; cancer stem cells; colon; mammary; prostate; therapeutics
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Valkenburg, K.C.; Graveel, C.R.; Zylstra-Diegel, C.R.; Zhong, Z.; Williams, B.O. Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers 2011, 3, 2050-2079.
Valkenburg KC, Graveel CR, Zylstra-Diegel CR, Zhong Z, Williams BO. Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers. 2011; 3(2):2050-2079.
Valkenburg, Kenneth C.; Graveel, Carrie R.; Zylstra-Diegel, Cassandra R.; Zhong, Zhendong; Williams, Bart O. 2011. "Wnt/β-catenin Signaling in Normal and Cancer Stem Cells." Cancers 3, no. 2: 2050-2079.