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Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
AbstractThe ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wnt/β-catenin signaling and how the pathway regulates normal differentiation of stem cells in the intestine, mammary gland, and prostate. We will also discuss how dysregulation of the pathway is associated with putative cancer stem cells and the potential therapeutic implications of regulating Wnt signaling.
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Valkenburg, K.C.; Graveel, C.R.; Zylstra-Diegel, C.R.; Zhong, Z.; Williams, B.O. Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers 2011, 3, 2050-2079.View more citation formats
Valkenburg KC, Graveel CR, Zylstra-Diegel CR, Zhong Z, Williams BO. Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers. 2011; 3(2):2050-2079.Chicago/Turabian Style
Valkenburg, Kenneth C.; Graveel, Carrie R.; Zylstra-Diegel, Cassandra R.; Zhong, Zhendong; Williams, Bart O. 2011. "Wnt/β-catenin Signaling in Normal and Cancer Stem Cells." Cancers 3, no. 2: 2050-2079.