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Therapeutic Approaches to Target Cancer Stem Cells
Department of Systems Biology, Center of Molecular Immunology, 216 Street, PO Box 16040, Atabey, Havana 11600, Cuba
* Author to whom correspondence should be addressed.
Received: 8 May 2011; in revised form: 27 July 2011 / Accepted: 7 August 2011 / Published: 15 August 2011
Abstract: The clinical relevance of cancer stem cells (CSC) remains a major challenge for current cancer therapies, but preliminary findings indicate that specific targeting may be possible. Recent studies have shown that these tumor subpopulations promote tumor angiogenesis through the increased production of VEGF, whereas the VEGF neutralizing antibody bevacizumab specifically inhibits CSC growth. Moreover, nimotuzumab, a monoclonal antibody against the epidermal growth factor receptor (EGFR) with a potent antiangiogenic activity, has been shown by our group to reduce the frequency of CSC-like subpopulations in mouse models of brain tumors when combined with ionizing radiation. These studies and subsequent reports from other groups support the relevance of approaches based on molecular-targeted therapies to selectively attack CSC. This review discusses the relevance of targeting both the EGFR and angiogenic pathways as valid approaches to this aim. We discuss the relevance of identifying better molecular markers to develop drug screening strategies that selectively target CSC.
Keywords: CSC; CD133; angiogenesis; EGFR
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Cite This Article
MDPI and ACS Style
Diaz, A.; Leon, K. Therapeutic Approaches to Target Cancer Stem Cells. Cancers 2011, 3, 3331-3352.
Diaz A, Leon K. Therapeutic Approaches to Target Cancer Stem Cells. Cancers. 2011; 3(3):3331-3352.
Diaz, Arlhee; Leon, Kalet. 2011. "Therapeutic Approaches to Target Cancer Stem Cells." Cancers 3, no. 3: 3331-3352.