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Cancers 2011, 3(3), 3331-3352; doi:10.3390/cancers3033331
Review

Therapeutic Approaches to Target Cancer Stem Cells

*  and
Received: 8 May 2011; in revised form: 27 July 2011 / Accepted: 7 August 2011 / Published: 15 August 2011
(This article belongs to the Special Issue Cancer Stem Cells)
View Full-Text   |   Download PDF [193 KB, uploaded 15 August 2011]
Abstract: The clinical relevance of cancer stem cells (CSC) remains a major challenge for current cancer therapies, but preliminary findings indicate that specific targeting may be possible. Recent studies have shown that these tumor subpopulations promote tumor angiogenesis through the increased production of VEGF, whereas the VEGF neutralizing antibody bevacizumab specifically inhibits CSC growth. Moreover, nimotuzumab, a monoclonal antibody against the epidermal growth factor receptor (EGFR) with a potent antiangiogenic activity, has been shown by our group to reduce the frequency of CSC-like subpopulations in mouse models of brain tumors when combined with ionizing radiation. These studies and subsequent reports from other groups support the relevance of approaches based on molecular-targeted therapies to selectively attack CSC. This review discusses the relevance of targeting both the EGFR and angiogenic pathways as valid approaches to this aim. We discuss the relevance of identifying better molecular markers to develop drug screening strategies that selectively target CSC.
Keywords: CSC; CD133; angiogenesis; EGFR CSC; CD133; angiogenesis; EGFR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Diaz, A.; Leon, K. Therapeutic Approaches to Target Cancer Stem Cells. Cancers 2011, 3, 3331-3352.

AMA Style

Diaz A, Leon K. Therapeutic Approaches to Target Cancer Stem Cells. Cancers. 2011; 3(3):3331-3352.

Chicago/Turabian Style

Diaz, Arlhee; Leon, Kalet. 2011. "Therapeutic Approaches to Target Cancer Stem Cells." Cancers 3, no. 3: 3331-3352.



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