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Cancers 2011, 3(1), 415-427; doi:10.3390/cancers3010415

Cancer Stem Cells in Head and Neck Cancer

1 Department of Pathology, University of Colorado Denver, AMC 12800 E. 19th Ave., Aurora, CO 80045, USA 2 Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, CO 80045, USA
* Author to whom correspondence should be addressed.
Received: 2 December 2010 / Revised: 24 December 2010 / Accepted: 14 January 2011 / Published: 20 January 2011
(This article belongs to the Special Issue Cancer Stem Cells)
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Head and neck cancer (HNC) is the sixth most common malignancy world-wide, however the survival rate has not improved for the past 20 years. In recent years, the cancer stem cell (CSC) hypothesis has gained ground in several malignancies and there is mounting evidence suggesting CSCs mediate tumor resistance to chemotherapy and radiation therapy. However, the CSC theory is also challenged at least in certain types of cancer. Here we review the progress of CSC studies in HNC, which suggest that HNC conforms to the CSC model. The identified CSC markers and their tumor initiation properties provide a framework for the development of novel therapeutic strategies for HNC.
Keywords: chemoresistance; radioresistance; transplantation; tumorigenicity chemoresistance; radioresistance; transplantation; tumorigenicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mitra, D.; Malkoski, S.P.; Wang, X.-J. Cancer Stem Cells in Head and Neck Cancer. Cancers 2011, 3, 415-427.

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