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Cancers 2011, 3(1), 415-427; doi:10.3390/cancers3010415
Review

Cancer Stem Cells in Head and Neck Cancer

1
, 2
 and 1,*
Received: 2 December 2010; in revised form: 24 December 2010 / Accepted: 14 January 2011 / Published: 20 January 2011
(This article belongs to the Special Issue Cancer Stem Cells)
View Full-Text   |   Download PDF [199 KB, uploaded 20 January 2011]
Abstract: Head and neck cancer (HNC) is the sixth most common malignancy world-wide, however the survival rate has not improved for the past 20 years. In recent years, the cancer stem cell (CSC) hypothesis has gained ground in several malignancies and there is mounting evidence suggesting CSCs mediate tumor resistance to chemotherapy and radiation therapy. However, the CSC theory is also challenged at least in certain types of cancer. Here we review the progress of CSC studies in HNC, which suggest that HNC conforms to the CSC model. The identified CSC markers and their tumor initiation properties provide a framework for the development of novel therapeutic strategies for HNC.
Keywords: chemoresistance; radioresistance; transplantation; tumorigenicity chemoresistance; radioresistance; transplantation; tumorigenicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mitra, D.; Malkoski, S.P.; Wang, X.-J. Cancer Stem Cells in Head and Neck Cancer. Cancers 2011, 3, 415-427.

AMA Style

Mitra D, Malkoski SP, Wang X-J. Cancer Stem Cells in Head and Neck Cancer. Cancers. 2011; 3(1):415-427.

Chicago/Turabian Style

Mitra, Doyel; Malkoski, Stephen P.; Wang, Xiao-Jing. 2011. "Cancer Stem Cells in Head and Neck Cancer." Cancers 3, no. 1: 415-427.



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