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Most Cited & Viewed - Cancers

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Citations	Article
366	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
245	Review: Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment by Theerawut Chanmee, Pawared Ontong, Kenjiro Konno and Naoki Itano
220	Review: Drug Resistance in Cancer: An Overview by Genevieve Housman, Shannon Byler, Sarah Heerboth, Karolina Lapinska, Mckenna Longacre, Nicole Snyder and Sibaji Sarkar
173	Review: Cell Death Pathways in Photodynamic Therapy of Cancer by Pawel Mroz, Anastasia Yaroslavsky, Gitika B Kharkwal and Michael R. Hamblin
154	Article: Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome by Marija Milacic, Robin Haw, Karen Rothfels, Guanming Wu, David Croft, Henning Hermjakob, Peter D'Eustachio and Lincoln Stein
137	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
100	Review: STAT3 Target Genes Relevant to Human Cancers by Richard L. Carpenter and Hui-Wen Lo
91	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
87	Review: Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin by Lara Gibellini, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza
86	Review: Cytokines in Cancer Immunotherapy by Sylvia Lee and Kim Margolin

Citations	Article
8	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
7	Review: Current Advances in Aptamers for Cancer Diagnosis and Therapy by Shin-ichiro Hori, Alberto Herrera, John J. Rossi and Jiehua Zhou
7	Review: Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy by Neus Martinez-Bosch, Judith Vinaixa and Pilar Navarro
7	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
4	Review: Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression by Ellie Rad, James T. Murray and Andrew R. Tee
3	Review: Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity by Alessia Stornetta, Valeria Guidolin and Silvia Balbo
3	Review: Aptamer Therapeutics in Cancer: Current and Future by Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, David E. Volk and Takemi Tanaka
3	Review: Targeted Therapies for Pancreatic Cancer by Idoroenyi Amanam and Vincent Chung
3	Review: mTOR Cross-Talk in Cancer and Potential for Combination Therapy by Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti and Michele Milella
2	Article: IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas by Cecilia Bandini, Aldi Pupuleku, Elisa Spaccarotella, Elisa Pellegrino, Rui Wang, Nicoletta Vitale, Carlotta Duval, Daniela Cantarella, Andrea Rinaldi, Paolo Provero, Ferdinando Di Cunto, Enzo Medico, Francesco Bertoni, Giorgio Inghirami and Roberto Piva

Citations	Article
17	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
13	Review: Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis by Ifigeneia V. Mavragani, Zacharenia Nikitaki, Maria P. Souli, Asef Aziz, Somaira Nowsheen, Khaled Aziz, Emmy Rogakou and Alexandros G. Georgakilas
8	Review: Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis by Trung Vu and Pran K. Datta
8	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
8	Review: The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition by Robert H. Blackwell, Kimberly E. Foreman and Gopal N. Gupta
7	Review: Current Advances in Aptamers for Cancer Diagnosis and Therapy by Shin-ichiro Hori, Alberto Herrera, John J. Rossi and Jiehua Zhou
7	Review: EMT and Treatment Resistance in Pancreatic Cancer by Nicola Gaianigo, Davide Melisi and Carmine Carbone
7	Review: Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy by Neus Martinez-Bosch, Judith Vinaixa and Pilar Navarro
7	Review: Integrin αvβ3 Signaling in Tumor-Induced Bone Disease by Kristin A. Kwakwa and Julie A. Sterling
7	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura

Citations	Article
40	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian van Straten, Vida Mashayekhi, Henriette S. de Bruijn, Sabrina Oliveira and Dominic J. Robinson
31	Review: Wnt5a Signaling in Cancer by Marwa S. Asem, Steven Buechler, Rebecca Burkhalter Wates, Daniel L. Miller and M. Sharon Stack
28	Review: Exosomes in Cancer Diagnostics by Young Hwa Soung, Shane Ford, Vincent Zhang and Jun Chung
25	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
23	Review: Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells by Richard Heery, Stephen P. Finn, Sinead Cuffe and Steven G. Gray
22	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
17	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
16	Review: Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials by Benjamin Lu, Brooke A. Green, Jacqueline M. Farr, Flávia C.M. Lopes and Terence J. Van Raay
16	Review: Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer by Kentaro Inamura
15	Review: Androgen Receptor: A Complex Therapeutic Target for Breast Cancer by Ramesh Narayanan and James T. Dalton

Citations	Article
91	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
85	Review: Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth by Kazuyoshi Shiga, Masayasu Hara, Takaya Nagasaki, Takafumi Sato, Hiroki Takahashi and Hiromitsu Takeyama
48	Review: Targeting RTK Signaling Pathways in Cancer by Tarik Regad
45	Review: MicroRNAs in Cancer: A Historical Perspective on the Path from Discovery to Therapy by Esteban A. Orellana and Andrea L. Kasinski
44	Review: Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy by Anna Maria Barbuti and Zhe-Sheng Chen
42	Review: Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges by Rajyalakshmi Luthra, Hui Chen, Sinchita Roy-Chowdhuri and R. Rajesh Singh
42	Review: The Clinical Relevance of Long Non-Coding RNAs in Cancer by Andreia Silva, Marc Bullock and George Calin
40	Review: Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions by Demian van Straten, Vida Mashayekhi, Henriette S. de Bruijn, Sabrina Oliveira and Dominic J. Robinson
39	Review: The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer by David P. Rose, Peter J. Gracheck and Linda Vona-Davis
39	Review: The Evolution of Therapies in Non-Small Cell Lung Cancer by Vishal Boolell, Muhammad Alamgeer, David N. Watkins and Vinod Ganju

» More Articles

Views	Article
19020	Review: *Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis* by Eun-Hee Kim, Kyung-Sook Hong, Hua Hong and Ki Baik Hahm
16333	Review: Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells by Ahmed Abdal Dayem, Hye-Yeon Choi, Jung-Hyun Kim and Ssang-Goo Cho
15710	Review: Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects by Ana-Maria Florea and Dietrich Büsselberg
13756	Review: Cancer Biomarkers: Are We Ready for the Prime Time? by Alok Mishra and Mukesh Verma
13452	Review: Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression by Ilaria Bellezza, Anna Lisa Mierla and Alba Minelli
11515	Review: Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins? by Dejuan Kong, Yiwei Li, Zhiwei Wang and Fazlul H. Sarkar
11508	Review: Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth? by Michael Retsky, Romano Demicheli, William Hrushesky, Michael Baum and Isaac Gukas
11158	Review: The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer by Stefania Pizzimenti, Cristina Toaldo, Piergiorgio Pettazzoni, Mario U. Dianzani and Giuseppina Barrera
10966	Review: Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin by Lara Gibellini, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza
10779	Review: Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer by Michael J. Wargovich, Vondina R. Brown and Jay Morris

Views	Article
2423	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine
2024	Review: Colorectal Cancers: An Update on Their Molecular Pathology by Kentaro Inamura
2013	Review: Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors by Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar
1954	Review: mTOR Pathways in Cancer and Autophagy by Mathieu Paquette, Leeanna El-Houjeiri and Arnim Pause
1750	Review: The Immunomodulatory Capacity of an Epstein-Barr Virus Abortive Lytic Cycle: Potential Contribution to Viral Tumorigenesis by Abigail Morales-Sánchez and Ezequiel M. Fuentes-Panana
1627	Review: Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer by Jiajia Zhang, Christopher L. Wolfgang and Lei Zheng
1581	Review: Bladder Cancer: New Insights into Its Molecular Pathology by Kentaro Inamura
1529	Review: Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy by Neus Martinez-Bosch, Judith Vinaixa and Pilar Navarro
1521	Review: The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer by Sandra Valle, Laura Martin-Hijano, Sonia Alcalá, Marta Alonso-Nocelo and Bruno Sainz Jr.
1517	Review: The Hippo Pathway: Immunity and Cancer by Zaid Taha, Helena J. Janse van Rensburg and Xiaolong Yang

Views	Article
3734	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
2536	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
2485	Article: CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth by Vita Golubovskaya, Robert Berahovich, Hua Zhou, Shirley Xu, Hizkia Harto, Le Li, Cheng-Chi Chao, Mike Ming Mao and Lijun Wu
2451	Review: Complex Determinants of Epithelial: Mesenchymal Phenotypic Plasticity in Ovarian Cancer by Yuliya Klymenko, Oleg Kim and M. Sharon Stack
2445	Review: The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer by Brock J. Sishc and Anthony J. Davis
2423	Review: The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It by Heather Armstrong, Michael Bording-Jorgensen, Stephanie Dijk and Eytan Wine
2299	Review: Pancreatic Cancer Chemoresistance to Gemcitabine by Manoj Amrutkar and Ivar P. Gladhaug
2266	Article: Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women by Yanyuan Wu, Marianna Sarkissyan, Sheilah Clayton, Rowan Chlebowski and Jaydutt V. Vadgama
2256	Review: The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas by Monica Fedele, Laura Cerchia and Gennaro Chiappetta
2132	Review: Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors by Joline S. J. Lim and David S. P. Tan

Views	Article
3734	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
3603	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang
3424	Review: Advances in Cancer Immunotherapy in Solid Tumors by Smitha Menon, Sarah Shin and Grace Dy
2878	Review: Wnt5a Signaling in Cancer by Marwa S. Asem, Steven Buechler, Rebecca Burkhalter Wates, Daniel L. Miller and M. Sharon Stack
2804	Review: Systemic Immunotherapy for Urothelial Cancer: Current Trends and Future Directions by Shilpa Gupta, David Gill, Austin Poole and Neeraj Agarwal
2690	Review: HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance by Babak Nami and Zhixiang Wang
2681	Review: Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer by Peter McAnena, James A. L. Brown and Michael J. Kerin
2601	Review: Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination by Laura Di Blasio, Paolo A. Gagliardi, Alberto Puliafito and Luca Primo
2536	Review: Exploring the Role of RGD-Recognizing Integrins in Cancer by Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger and Horst Kessler
2530	Review: The Receptor Tyrosine Kinase AXL in Cancer Progression by Erinn B. Rankin and Amato J. Giaccia

Views	Article
7215	Review: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors by Tadas K. Rimkus, Richard L. Carpenter, Shadi Qasem, Michael Chan and Hui-Wen Lo
6989	Review: Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy by Vita Golubovskaya and Lijun Wu
4829	Review: The Evolution of Therapies in Non-Small Cell Lung Cancer by Vishal Boolell, Muhammad Alamgeer, David N. Watkins and Vinod Ganju
4312	Review: Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges by Rajyalakshmi Luthra, Hui Chen, Sinchita Roy-Chowdhuri and R. Rajesh Singh
4246	Review: Targeting RTK Signaling Pathways in Cancer by Tarik Regad
3775	Review: The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer by David P. Rose, Peter J. Gracheck and Linda Vona-Davis
3753	Review: Not All Next Generation Sequencing Diagnostics are Created Equal: Understanding the Nuances of Solid Tumor Assay Design for Somatic Mutation Detection by Phillip N. Gray, Charles L.M. Dunlop and Aaron M. Elliott
3734	Review: Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM) by Astero Klampatsa, Andrew R. Haas, Edmund K. Moon and Steven M. Albelda
3656	Review: Melanoma Cancer Stem Cells: Markers and Functions by Giorgio Parmiani
3603	Review: Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways by Ping Wee and Zhixiang Wang

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