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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer Immunotherapy as Part of Precision Clinical Medicine

edited by

Peter Lang

and

Christo Kole

submission deadline 10 Oct 2026 | 4 articles | Viewed by 9645 | Submission Open

Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Oreste Gallo

submission deadline 10 Oct 2026 | 3 articles | Viewed by 6107 | Submission Open

Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx

(This special issue belongs to the Section Cancer Therapy)

Advances in Diagnostics and Treatments for Glioblastoma

edited by Sied Kebir and

Manmeet Singh Ahluwalia

submission deadline 10 Oct 2026 | 2 articles | Viewed by 4252 | Submission Open

Keywords: glioblastoma; molecular diagnostics; neuro-oncology; imaging biomarkers; immunotherapy; targeted therapy; tumor-treating fields; radiotherapy; chemotherapy; translational research; machine learning; positron emission tomography

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Mitochondrial Metabolism in Cancer Immune Responses

edited by

Jae Ho Seo

and Kiwon Lee

submission deadline 10 Oct 2026 | 2 articles | Viewed by 2806 | Submission Open

Keywords: mitochondria; cancer metabolism; immune response; tumor microenvironment (TME); immunometabolism; mitochondrial reprogramming; reactive oxygen species (ROS); cancer immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Multidisciplinary Advances and Surgical Impact in Brain and Central Nervous System Tumors: From Molecular Insights to Clinical Outcomes

edited by Paolo Tini, Salvatore Chibbaro and

Mario Ganau

submission deadline 10 Oct 2026 | 1 articles | Viewed by 2116 | Submission Open

Keywords: glioblastoma; low-grade gliomas; ependymomas; PNET; meningiomas; medulloblastomas; other brain tumors

Pioneering Advances in Neurosurgical Oncology: From Innovative Techniques to Better Patient Outcomes

edited by

Oreste de Divitiis

and

Massimiliano Visocchi

submission deadline 10 Oct 2026 | Viewed by 757 | Submission Open

Keywords: endoscope; 3D exoscope; tractography MRI; molecular biomarkers; stem cells; transoral; cordomas; skullbase

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Insights into the Etiology of Lymphoma

edited by Susan L. Slager and James R. Cerhan

submission deadline 15 Oct 2026 | 4 articles | Viewed by 5093 | Submission Open

Keywords: lymphoma etiology; genetic predisposition; clonal hematopoiesis; precursor conditions; risk stratification; viral oncogenesis; non-Hodgkin lymphoma; Hodgkin lymphoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Brain Tumors—Related Cognitive Impairment

edited by

Djaina Satoer

and

Anne Marie Buunk

submission deadline 15 Oct 2026 | 2 articles | Viewed by 2252 | Submission Open

Keywords: aphasia; cognition; brain tumor; surgery; adjuvant treatment; rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition

edited by

Alba Scerrati

and Giorgio Mantovani

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1965 | Submission Open

Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Strategies for the Treatment of Melanoma in Neoadjuvant and Adjuvant Settings

edited by Michele Del Vecchio

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1717 | Submission Open

Keywords: melanoma; adjuvant therapy; neoadjuvant therapy; treatment

(This special issue belongs to the Section Cancer Therapy)

Cancer Rehabilitation and Physical Activity: Advancing Function, Recovery, and Quality of Life Across the Cancer Continuum

edited by Jennifer Michelle Jones

submission deadline 15 Oct 2026 | 1 articles | Viewed by 1035 | Submission Open

Keywords: cancer rehabilitation; exercise science; physical activity; prehabilitation; adverse side effects

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Molecular Pathology-Driven Approaches to Improve Cancer Diagnostic Accuracy

edited by

Ovidiu Laurean Pop

submission deadline 15 Oct 2026 | 1 articles | Viewed by 992 | Submission Open

Keywords: molecular pathology; cancer diagnostics; precision oncology; genomic profiling; digital pathology; artificial intelligence; predictive biomarkers; prognostic biomarkers; translational oncology

(This special issue belongs to the Section Cancer Pathophysiology)

World Lung Cancer Awareness Month: 2nd Edition

edited by

Calvin Sze Hang Ng

submission deadline 15 Oct 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: lung cancer; tumor microenvironment; early detection; therapeutic targets; new therapeutic strategies; surgery; genetics

(This special issue belongs to the Section Cancer Therapy)

Genetic and Molecular Characterization of Lung Cancer

edited by Sk Kayum Alam

submission deadline 15 Oct 2026 | 1 articles | Viewed by 836 | Submission Open

Keywords: lung cancer; molecular subtypes of lung cancer; genetic alterations; next-generation sequencing; biomarker; oncogenic driver mutations; therapeutic landscapes; treatment resistance; metastasis

(This special issue belongs to the Section Molecular Cancer Biology)

Evolving Paradigms in Minimally Invasive and Ablative Endocrine Thyroid Surgery

edited by Gianlorenzo Dionigi and

Francesco Brucchi

submission deadline 15 Oct 2026 | Viewed by 360 | Submission Open

Keywords: minimally invasive thyroid surgery; transoral endoscopic thyroidectomy; TOETVA; MIVAT; percutaneous thermal ablation; radiofrequency ablation; microwave ablation; active surveillance; papillary thyroid microcarcinoma; benign thyroid nodules; complication prevention; intraoperative nerve monitoring; health economics in surgery; multidisciplinary approach; surgical innovation; temporal trends in surgery; molecular profiling thyroid; surgical outcomes

(This special issue belongs to the Section Clinical Research in Cancer)

Navigating Therapeutic Resistance in Lung Cancer

edited by

Luca Grumolato

submission deadline 15 Oct 2026 | Viewed by 254 | Submission Open

Keywords: non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immune therapy; immune checkpoint inhibitors; drug persister cells; resistance; drug tolerance

(This special issue belongs to the Section Cancer Therapy)

Neuroradiology of Brain Tumors: Radiomics Features and Imaging Technologies

edited by Harpreet Hyare

submission deadline 15 Oct 2026 | Viewed by 206 | Submission Open

Keywords: MRI; radiomics; PET; sodium; perfusion; diffusion; glioma; pediatrics; machine learning

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

A Renewed Understanding of Tumor Growth Modulation by Tumor Necrosis Factor (TNF)-Associated Pathways

edited by Chandra Shekhar Boosani

submission deadline 15 Oct 2026 | Viewed by 206 | Submission Open

Keywords: tumor; inflammation; epigenetics; immune system; inhibitors

(This special issue belongs to the Section Molecular Cancer Biology)

The Role of Digital Platforms in Transforming Cancer Surgery and Patient Care

edited by Sang-ho Jeong and

Jae-seok Min

submission deadline 16 Oct 2026 | 1 articles | Viewed by 1109 | Submission Open

Keywords: digital health platforms; surgical oncology; minimally invasive surgery; patient care management

Diagnosis and Therapy in Urothelial Cancer

edited by

Giuseppe Palermo

submission deadline 20 Oct 2026 | 4 articles | Viewed by 4773 | Submission Open

Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma

(This special issue belongs to the Section Cancer Therapy)

Thyroid Cancer Recurrence: Integrating Surgical, Clinical, and Translational Research

edited by

Nikola Slijepcevic

and Ioannis Koutelidakis

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3139 | Submission Open

Keywords: thyroid cancer; recurrence; surgery; clinical management; aggressive subtypes; rare subtypes; biomarkers; imaging; translational research; targeted therapy

(This special issue belongs to the Section Clinical Research in Cancer)

Advancing Precision Oncology: From Biomarker Discovery to Clinical Validation

edited by

Manoj Pandey

and

Ruhi Dixit

submission deadline 20 Oct 2026 | 2 articles | Viewed by 978 | Submission Open

Keywords: precision medicine; biomarkers; clinical translation; medical oncology; liquid biopsy

(This special issue belongs to the Section Cancer Biomarkers)

Locally Advanced and Recurrent Pelvic Malignancy

edited by Paul Anthony Sutton

submission deadline 20 Oct 2026 | 1 articles | Viewed by 555 | Submission Open

Keywords: pelvic malignancy; locally advanced; recurrent; treament; translational research

The Future of Precision Radiotherapy for Cancer: Technology, Optimization, and Clinical Integration

edited by Thomas J. Fitzgerald

submission deadline 20 Oct 2026 | Viewed by 428 | Submission Open

Keywords: radiation; proton; photon; brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care

edited by Roberto Berretta

submission deadline 20 Oct 2026 | Viewed by 387 | Submission Open

Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping

(This special issue belongs to the Section Cancer Therapy)

Discovery of Novel Therapeutic Targets in Multiple Myeloma

edited by

Hiroshi Handa

submission deadline 23 Oct 2026 | Viewed by 266 | Submission Open

Keywords: multiple myeloma; therapeutic target; immunotherapy; drug resistance

Radiation Therapy for Brain Tumors

edited by

Jim Zhong

submission deadline 25 Oct 2026 | 4 articles | Viewed by 16161 | Submission Open

Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife

(This special issue belongs to the Section Cancer Therapy)

Advances in Interventional Oncology in Hepatocellular Carcinoma Treatment

edited by Edward W. Lee, XiaoLi Zhu and Frank Hao

submission deadline 25 Oct 2026 | 2 articles | Viewed by 2766 | Submission Open

Keywords: hepatocellular carcinoma; interventional oncology; HCC

(This special issue belongs to the Section Cancer Therapy)

Skin Cancer Prevention: Strategies, Challenges and Future Directions

edited by Véronique del Marmol, Mariano Suppa, Ana-Maria Forsea and Alexander Stratigos

submission deadline 30 Oct 2026 | 8 articles | Viewed by 19980 | Submission Open

Keywords: skin cancer prevention; photoprotection; early detection; screening; epidemiology; public health; behavioral interventions; sun exposure; artificial intelligence; risk factors

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Neurofibromatosis

edited by Yunjia Chen and Yulong Fu

submission deadline 30 Oct 2026 | 2 articles | Viewed by 12552 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1

Adverse Effects During Cancer Treatment

edited by Yan Gong

submission deadline 30 Oct 2026 | 4 articles | Viewed by 4329 | Submission Open

Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Recent Advances and Strategies for the Management of CIN and HPV Eradication Strategies for the Prevention of Uterine Cervical Cancer

edited by

Masaru Sakamoto

submission deadline 30 Oct 2026 | 1 articles | Viewed by 3902 | Submission Open

Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT

Cancer Prevention and Screening: Innovations, Implementation, and Access

edited by

Jaclyn M. Hall

and Rahma S. Mkuu

submission deadline 30 Oct 2026 | 4 articles | Viewed by 3677 | Submission Open

Keywords: cancer; prevention; screening; intervention; implementation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Neurosurgery Research on Brain Tumors

edited by

Toshihide Tanaka

submission deadline 30 Oct 2026 | 3 articles | Viewed by 2694 | Submission Open

Keywords: neuro-oncology; neurosurgical technique; brain tumors; neuroimages

Gynecological Cancers: From Bench to Bedside

edited by

Francesco Cosentino

submission deadline 30 Oct 2026 | 2 articles | Viewed by 2616 | Submission Open

Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Translational Insights into the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: Integrating Mechanistic, Clinical and Therapeutic Advances

edited by Ellen M. Lavoie Smith

submission deadline 30 Oct 2026 | 3 articles | Viewed by 2598 | Submission Open

Keywords: chemotherapy-induced peripheral neuropathy; mechanisms; treatment; prevention; assessment; biomarkers

Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications

edited by

Appu Rathinavelu

and Umamaheswari Natarajan

submission deadline 30 Oct 2026 | 1 articles | Viewed by 2524 | Submission Open

Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1, DNMT3A, DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA

(This special issue belongs to the Section Molecular Cancer Biology)

Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers

edited by

Linhui Wang

and

Aimin Jiang

submission deadline 30 Oct 2026 | 3 articles | Viewed by 2000 | Submission Open

Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Clinical Research of Brachytherapy in Cancer

edited by Ludmiła Grzybowska-Szatkowska,

Paweł Cisek

and Aleksandra Kozłowska

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1383 | Submission Open

Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm

(This special issue belongs to the Section Clinical Research in Cancer)

Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research

edited by

Xuemei Xie

and Tamer Saad Kaoud

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1307 | Submission Open

Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research

(This special issue belongs to the Section Clinical Research in Cancer)

The Current Status of Brain Tumor Imaging: 2nd Edition

edited by

Houman Sotoudeh

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1101 | Submission Open

Keywords: neuro-oncology; glioma; brain metastasis; CT scan; MRI; radiogenomics; radiomics; artificial intelligence; MR spectroscopy; MR perfusion; fMRI

(This special issue belongs to the Section Cancer Therapy)

Research and Clinical Applications of Gynecologic Cancer Detection Technologies

edited by Porfyrios Korompelis

submission deadline 30 Oct 2026 | 1 articles | Viewed by 906 | Submission Open

Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies

(This special issue belongs to the Section Methods and Technologies Development)

Innovations in Pancreatic Oncology: Surgical Outcomes, Biomarkers, and Artificial Intelligence

edited by Jayasree Chakraborty and Lily Saadat

submission deadline 30 Oct 2026 | 1 articles | Viewed by 706 | Submission Open

Keywords: pancreatic cancer; oncology; early detection; surgical outcome; biomarkers; multi-modal data; artificial intelligenec; clinical decision support system; precision medicine

MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions

edited by Wadie Mahauad Fernandez and Konstantinos V. Floros

submission deadline 30 Oct 2026 | Viewed by 629 | Submission Open

Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Gastrointestinal Tumors: Screening and Prevention

edited by

Hans Scherübl

submission deadline 30 Oct 2026 | 1 articles | Viewed by 498 | Submission Open

Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy

The Role of Sphingolipids in Cancer Progression

edited by

Jeremy Hengst

submission deadline 30 Oct 2026 | Viewed by 427 | Submission Open

Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development

(This special issue belongs to the Section Molecular Cancer Biology)

Hyperthermic Intraperitoneal Chemotherapy in Oncology: Current Clinical Applications and Future Directions

edited by Konstantinos I. Votanopoulos

submission deadline 30 Oct 2026 | Viewed by 326 | Submission Open

Keywords: HIPEC; cytoreductive surgery; peritoneal surface malignancies; colorectal cancer; appendiceal neoplasms; gastric cancer; ovarian cancer; peritoneal mesothelioma; intraperitoneal chemotherapy-organoids

(This special issue belongs to the Section Cancer Therapy)

Surgical Management of Colorectal Cancer: Current Standards and Future Directions

edited by Pedro Silva-Vaz and

Marta Costa

submission deadline 30 Oct 2026 | Viewed by 319 | Submission Open

Keywords: colorectal cancer; colorectal surgery; robotic-assisted surgery; transanal surgery; organ preservation; neoadjuvant therapy; perioperative optimization; cancer imaging; artificial intelligence; multidisciplinary approach

(This special issue belongs to the Section Cancer Therapy)

Advances in Immunotherapy, Biomarkers, and Clinical Practice in Pleural Mesothelioma and Thoracic Cancers

edited by

Mario Occhipinti

submission deadline 30 Oct 2026 | Viewed by 277 | Submission Open

Keywords: pleural mesothelioma; thoracic cancers; immunotherapy; biomarkers; immunotherapy resistance; molecular and genetic testing; precision oncology; real-world clinical practice

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Biomarkers in Human Testicular Germ Cell Tumors: Targets for Therapeutic, Diagnostic and Follow-Up Strategies

edited by

Marko Zivkovic

Uroš Bumbaširević

and

Milica Zeković

submission deadline 30 Oct 2026 | Viewed by 248 | Submission Open

Keywords: testicular germ cell tumors (TGCTs); molecular biomarkers; miRNA; liquid biopsy; circulating tumor DNA (ctDNA); diagnostic biomarkers; therapeutic targets; follow-up/surveillance

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