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Brain Cancer Stem Cells: Current Status on Glioblastoma Multiforme
Developmental Biology Laboratory, Hopital Maisonneuve-Rosemont, 5415 Boul. l’Assomption, Montreal, H1T 2M4, Canada
Faculté de Médecine, Université de Montréal, Montréal, H3T 1J4, Canada
* Author to whom correspondence should be addressed.
Received: 22 February 2011; in revised form: 3 March 2011 / Accepted: 22 March 2011 / Published: 30 March 2011
Abstract: Glioblastoma multiforme (GBM), an aggressive brain tumor of astrocytic/neural stem cell origin, represents one of the most incurable cancers. GBM tumors are highly heterogeneous. However, most tumors contain a subpopulation of cells that display neural stem cell characteristics in vitro and that can generate a new brain tumor upon transplantation in mice. Hence, previously identified molecular pathways regulating neural stem cell biology were found to represent the cornerstone of GBM stem cell self-renewal mechanism. GBM tumors are also notorious for their resistance to radiation therapy. Notably, GBM “cancer stem cells” were also found to be responsible for this radioresistance. Herein, we will analyze the data supporting or not the cancer stem cell model in GBM, overview the current knowledge regarding GBM stem cell self-renewal and radioresistance molecular mechanisms, and discuss the potential therapeutic application of these findings.
Keywords: polycomb, BMI1; cancer stem cell; glioma; glioblastoma multiforme; astrocyte; astrocytoma; radioresistance; CD133; prominin
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Facchino, S.; Abdouh, M.; Bernier, G. Brain Cancer Stem Cells: Current Status on Glioblastoma Multiforme. Cancers 2011, 3, 1777-1797.
Facchino S, Abdouh M, Bernier G. Brain Cancer Stem Cells: Current Status on Glioblastoma Multiforme. Cancers. 2011; 3(2):1777-1797.
Facchino, Sabrina; Abdouh, Mohamed; Bernier, Gilbert. 2011. "Brain Cancer Stem Cells: Current Status on Glioblastoma Multiforme." Cancers 3, no. 2: 1777-1797.