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Cancer Stem Cells of Differentiated B-Cell Malignancies: Models and Consequences
INSERM, UMR1037-Cancer Research Center of Toulouse, 31300 Toulouse, France
ERL 5294 CNRS, BP3028 CHU Purpan, 31300 Toulouse, France
Université Toulouse III Paul-Sabatier, 31300 Toulouse, France
Service d’Hématologie, CHU Purpan, 31300 Toulouse, France
* Author to whom correspondence should be addressed.
Received: 18 February 2011; in revised form: 21 March 2011 / Accepted: 21 March 2011 / Published: 25 March 2011
Abstract: The concept of cancer stem cells has revolutionized our current vision of cancer development and was validated in solid tumors and cancers of the primitive hematopoietic compartment. Proof of the principle is still lacking, however, in malignancies of differentiated B-cells. We review here the current literature, which nevertheless suggests hierarchical organizations of the tumor clone for mostly incurable B-cell cancers such as multiple myeloma, lymphomas and B-chronic lymphocytic leukemia. We propose two models accounting for cancer stem cells in these contexts: a “top-to-bottom” clonal hierarchy from memory B-cells and a “bottom-to-top” model of clonal reprogramming. Selection pressure on the growing tumor can drive such reprogramming and increase its genetic diversity.
Keywords: cancer stem cell; B-Lymphoma; multiple myeloma; B-CLL; differentiated B malignancy; memory B cell; reprogramming
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Gross, E.; Quillet-Mary, A.; Ysebaert, L.; Laurent, G.; Fournie, J.-J. Cancer Stem Cells of Differentiated B-Cell Malignancies: Models and Consequences. Cancers 2011, 3, 1566-1579.
Gross E, Quillet-Mary A, Ysebaert L, Laurent G, Fournie J-J. Cancer Stem Cells of Differentiated B-Cell Malignancies: Models and Consequences. Cancers. 2011; 3(2):1566-1579.
Gross, Emilie; Quillet-Mary, Anne; Ysebaert, Loic; Laurent, Guy; Fournie, Jean-Jacques. 2011. "Cancer Stem Cells of Differentiated B-Cell Malignancies: Models and Consequences." Cancers 3, no. 2: 1566-1579.