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Cancers 2011, 3(1), 621-635; doi:10.3390/cancers3010621

Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells

1
Surgical and Molecular Neuro-Oncology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
2
Howard Hughes Medical Institute, National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
These authors contributed equally to the work.
*
Author to whom correspondence should be addressed.
Received: 22 November 2010 / Revised: 14 December 2010 / Accepted: 26 January 2011 / Published: 10 February 2011
(This article belongs to the Special Issue Cancer Stem Cells)
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Abstract

Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.
Keywords: tumor stem cell; glioma stem cell; malignant glioma; glioblastoma; treatment resistance; chemotherapy; radiation therapy tumor stem cell; glioma stem cell; malignant glioma; glioblastoma; treatment resistance; chemotherapy; radiation therapy
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Schmalz, P.G.; Shen, M.J.; Park, J.K. Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells. Cancers 2011, 3, 621-635.

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