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Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells
Surgical and Molecular Neuro-Oncology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Howard Hughes Medical Institute, National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
These authors contributed equally to the work.
* Author to whom correspondence should be addressed.
Received: 22 November 2010; in revised form: 14 December 2010 / Accepted: 26 January 2011 / Published: 10 February 2011
Abstract: Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.
Keywords: tumor stem cell; glioma stem cell; malignant glioma; glioblastoma; treatment resistance; chemotherapy; radiation therapy
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Cite This Article
MDPI and ACS Style
Schmalz, P.G.; Shen, M.J.; Park, J.K. Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells. Cancers 2011, 3, 621-635.
Schmalz PG, Shen MJ, Park JK. Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells. Cancers. 2011; 3(1):621-635.
Schmalz, Philip G.; Shen, Michael J.; Park, John K. 2011. "Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells." Cancers 3, no. 1: 621-635.