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Cancers 2011, 3(2), 2655-2666; doi:10.3390/cancers3022655

Glioblastoma Stem-Like Cells—Biology and Therapeutic Implications

* ,
Laboratory for Translational Brain Tumor and Stem Cell Research, Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York, NY 10021, USA
* Authors to whom correspondence should be addressed.
Received: 4 March 2011 / Revised: 4 May 2011 / Accepted: 31 May 2011 / Published: 10 June 2011
(This article belongs to the Special Issue Cancer Stem Cells)
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The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) from patient-derived GBM tissue samples. The hallmarks of TSCs are that they must be able to self-renew and retain tumorigenicity. The isolation, optimization and derivation of TSCs as outlined in this review, will be important in understanding biology and therapeutic applications related to these cells.
Keywords: glioblastoma multiforme; stem-like cells; brain tumor stem cells; differentiation; culturing; stem-cell hypothesis glioblastoma multiforme; stem-like cells; brain tumor stem cells; differentiation; culturing; stem-cell hypothesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gürsel, D.B.; Shin, B.J.; Burkhardt, J.-K.; Kesavabhotla, K.; Schlaff, C.D.; Boockvar, J.A. Glioblastoma Stem-Like Cells—Biology and Therapeutic Implications. Cancers 2011, 3, 2655-2666.

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