Cancers 2011, 3(2), 2169-2175; doi:10.3390/cancers3022169

X Inactivation and Progenitor Cancer Cells

Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Received: 11 February 2011; in revised form: 16 March 2011 / Accepted: 12 April 2011 / Published: 26 April 2011
(This article belongs to the Special Issue Cancer Stem Cells)
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Abstract: In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.
Keywords: X inactivation; Xist RNA; chromatin; cancer; epigenetics

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MDPI and ACS Style

Agrelo, R. X Inactivation and Progenitor Cancer Cells. Cancers 2011, 3, 2169-2175.

AMA Style

Agrelo R. X Inactivation and Progenitor Cancer Cells. Cancers. 2011; 3(2):2169-2175.

Chicago/Turabian Style

Agrelo, Ruben. 2011. "X Inactivation and Progenitor Cancer Cells." Cancers 3, no. 2: 2169-2175.

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