- freely available
X Inactivation and Progenitor Cancer Cells
AbstractIn mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.
Share & Cite This Article
Agrelo, R. X Inactivation and Progenitor Cancer Cells. Cancers 2011, 3, 2169-2175.View more citation formats
Agrelo R. X Inactivation and Progenitor Cancer Cells. Cancers. 2011; 3(2):2169-2175.Chicago/Turabian Style
Agrelo, Ruben. 2011. "X Inactivation and Progenitor Cancer Cells." Cancers 3, no. 2: 2169-2175.