Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Cancers 2011, 3(2), 2169-2175; doi:10.3390/cancers3022169
Review

X Inactivation and Progenitor Cancer Cells

Received: 11 February 2011; in revised form: 16 March 2011 / Accepted: 12 April 2011 / Published: 26 April 2011
(This article belongs to the Special Issue Cancer Stem Cells)
View Full-Text   |   Download PDF [133 KB, updated 27 April 2011; original version uploaded 26 April 2011]
Abstract: In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.
Keywords: X inactivation; Xist RNA; chromatin; cancer; epigenetics X inactivation; Xist RNA; chromatin; cancer; epigenetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Agrelo, R. X Inactivation and Progenitor Cancer Cells. Cancers 2011, 3, 2169-2175.

AMA Style

Agrelo R. X Inactivation and Progenitor Cancer Cells. Cancers. 2011; 3(2):2169-2175.

Chicago/Turabian Style

Agrelo, Ruben. 2011. "X Inactivation and Progenitor Cancer Cells." Cancers 3, no. 2: 2169-2175.



Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert