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X Inactivation and Progenitor Cancer Cells
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria
Received: 11 February 2011; in revised form: 16 March 2011 / Accepted: 12 April 2011 / Published: 26 April 2011
Abstract: In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.
Keywords: X inactivation; Xist RNA; chromatin; cancer; epigenetics
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Cite This Article
MDPI and ACS Style
Agrelo, R. X Inactivation and Progenitor Cancer Cells. Cancers 2011, 3, 2169-2175.
Agrelo R. X Inactivation and Progenitor Cancer Cells. Cancers. 2011; 3(2):2169-2175.
Agrelo, Ruben. 2011. "X Inactivation and Progenitor Cancer Cells." Cancers 3, no. 2: 2169-2175.