Cancers 2011, 3(1), 319-339; doi:10.3390/cancers3010319
Review

The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response

1email, 2email, 3email, 4email and 5,* email
Received: 1 December 2010; in revised form: 17 December 2010 / Accepted: 10 January 2011 / Published: 14 January 2011
(This article belongs to the Special Issue Cancer Stem Cells)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Colorectal cancer is the third-leading cause of cancer related mortality in the United States. The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. In parallel with this, experiment evidence has emerged supporting the century old hypothesis that solid tumor initiation, progression, chemoresistance and recurrence is the result of a small population of cancer cells with self-renewal and pluripotency capabilities. These “cancer stem cells” (CSCs) present a unique opportunity to better understand the biology of solid tumors in general, as well as targets for future therapeutics. In this review, we will summarize the current understanding of intestinal stem cell biology and translate it to colorectal CSCs to provide a basis for understanding chemoresistance, cancer recurrence and metastasis. A more complete understanding of the biology of colorectal CSCs will translate into the development of better chemotherapeutic and biological agents for the treatment of colorectal cancer.
Keywords: colon cancer; metastatic; cancer stem cell
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MDPI and ACS Style

Anderson, E.C.; Hessman, C.; Levin, T.G.; Monroe, M.M.; Wong, M.H. The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response. Cancers 2011, 3, 319-339.

AMA Style

Anderson EC, Hessman C, Levin TG, Monroe MM, Wong MH. The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response. Cancers. 2011; 3(1):319-339.

Chicago/Turabian Style

Anderson, Eric C.; Hessman, Crystal; Levin, Trevor G.; Monroe, Marcus M.; Wong, Melissa H. 2011. "The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response." Cancers 3, no. 1: 319-339.

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