Next Article in Journal
Why Victory in the War on Cancer Remains Elusive: Biomedical Hypotheses and Mathematical Models
Next Article in Special Issue
Cancer Stem Cells in Head and Neck Cancer
Previous Article in Journal
Cancer Stem Cells and Pediatric Solid Tumors
Previous Article in Special Issue
Prospects and Limitations of Using Endogenous Neural Stem Cells for Brain Regeneration
Cancers 2011, 3(1), 319-339; doi:10.3390/cancers3010319

The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response

Received: 1 December 2010 / Revised: 17 December 2010 / Accepted: 10 January 2011 / Published: 14 January 2011
(This article belongs to the Special Issue Cancer Stem Cells)
View Full-Text   |   Download PDF [333 KB, uploaded 14 January 2011]   |   Browse Figures


Colorectal cancer is the third-leading cause of cancer related mortality in the United States. The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. In parallel with this, experiment evidence has emerged supporting the century old hypothesis that solid tumor initiation, progression, chemoresistance and recurrence is the result of a small population of cancer cells with self-renewal and pluripotency capabilities. These “cancer stem cells” (CSCs) present a unique opportunity to better understand the biology of solid tumors in general, as well as targets for future therapeutics. In this review, we will summarize the current understanding of intestinal stem cell biology and translate it to colorectal CSCs to provide a basis for understanding chemoresistance, cancer recurrence and metastasis. A more complete understanding of the biology of colorectal CSCs will translate into the development of better chemotherapeutic and biological agents for the treatment of colorectal cancer.
Keywords: colon cancer; metastatic; cancer stem cell colon cancer; metastatic; cancer stem cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Anderson, E.C.; Hessman, C.; Levin, T.G.; Monroe, M.M.; Wong, M.H. The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response. Cancers 2011, 3, 319-339.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert