Guest Editor Dr. David Safronetz
Laboratory of Virology, NIAID, Building 28, Room 2A100A 903 4th Street Hamilton, MT 59840, USA
Special Issue Information
The genus hantavirus is comprised of a unique group of viruses within the Bunyaviridae which are maintained in nature and transmitted to humans via small vertebrates, predominantly rodents. In humans hantaviruses, including Hantaan, Dobrava, Puumala, Sin Nombre and Andes viruses, are responsible for two diseases; hemorrhagic fever with renal syndrome (HFRS) and the more recently recognized hantavirus pulmonary syndrome (HPS). Combined hantaviruses have a world-wide distribution with HFRS primarily occurring in Europe and Asia with an incidence of greater than 100,000 cases annually and mortality rates of up to 15%, and HPS documented throughout the America’s with mortality rates often exceeding 30%. Despite the significant morbidity and mortality associated with this group of pathogens vaccines, antivirals and therapeutics are largely non-existent. The past several years has seen renewed research interest on several aspects of hantaviruses. The present Special Issue covers recent developments in hantavirus biology, including ecology, clinical presentation and diagnostic approaches, molecular pathogenesis, mechanisms of virus-host cell interaction, disease modeling and the development of novel therapeutic strategies against these important pathogens.
Dr. Heinz Feldmann Dr. David Safronetz Guest Editors
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