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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hepatitis B Virus—Mechanisms of Persistence and Progress Towards a Cure

edited by

Qiong Zhao

and

Yongzhen Liu

submission deadline 16 Sep 2026 | Viewed by 511 | Submission Open

Keywords: hepatitis B virus (HBV); animal models; viral–host interactions; immune responses; pathogenesis; antivirals; HBV persistence

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coronaviruses Pathogenesis, Immunity, and Antivirals (2nd Edition)

edited by

Wentao Li

and Fei Yu

submission deadline 30 Sep 2026 | 15 articles | Viewed by 26016 | Submission Open

Keywords: coronavirus; pathogenesis; molecular; vaccines; evolution; immunity; antivirals

(This special issue belongs to the Section Coronaviruses)

Viral Diseases of Domestic Animals

edited by

Scott P. Kenney

submission deadline 30 Sep 2026 | 7 articles | Viewed by 15722 | Submission Open

Keywords: viral diseases; emerging infections; domestic animals; epidemiology; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 30 Sep 2026 | 9 articles | Viewed by 11009 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Herpesviruses and Associated Diseases, 2nd Edition

edited by

Sherif T.S. Hassan

submission deadline 30 Sep 2026 | 4 articles | Viewed by 8297 | Submission Open

Keywords: human herpesviruses; animal herpesviruses; viral latency and reactivation; immune evasion strategies; herpesvirus–host interactions; herpesvirus biology and pathogenesis; herpesvirus diagnosis; environmental factors; herpesvirus-associated diseases; prevention and treatment strategies; antiviral therapies; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Wastewater-Based Epidemiology and Viral Surveillance

edited by

Elisabetta Carraro

Cristina Pignata

and

Silvia Bonetta

submission deadline 30 Sep 2026 | 5 articles | Viewed by 7877 | Submission Open

Keywords: wastewater‐based epidemiology; WBE; viral surveillance; virus shedding; sewage; viral dynamics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Pestivirus 2026

edited by

Benjamin J. Lamp

and Christiane M. Riedel

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6654 | Submission Open

Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF

(This special issue belongs to the Section Animal Viruses)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6647 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Progress and Prospects in Oncolytic Virotherapy 2025–2026

edited by

Arianna Calistri

and

Sandra Tuyaerts

submission deadline 30 Sep 2026 | 2 articles | Viewed by 6221 | Submission Open

Keywords: oncovirotherapy; chemotherapy; preclinical studies; clinical trials; combinatory strategy; safety profile; therapeutic efficacy; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cross-Pathogen Insights into Infectious Diseases: From Biomarkers to Burden and Therapeutic Strategies of Viral Pathogens

edited by

Karolina Akinosoglou

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5882 | Submission Open

Keywords: cross-pathogen perspective; biomarkers; viral sepsis; therapeutic landscape

(This special issue belongs to the Section General Virology)

Nucleocytoviricota

edited by Natalya Yutin

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5386 | Submission Open

Keywords: Nucleocytoviricota; giant viruses; virophages; host–virus (-virophage) interactions; virion structure; viral ecology; diversity and classification; evolution of Nucleocytoviricota

(This special issue belongs to the Section General Virology)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5194 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

Coronavirus Therapy: Antiviral Drugs and Anti-Inflammatory Immunopharmacology

edited by

Chengyuan Liang

Lei Tian

and

Mengzhou Wang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3554 | Submission Open

Keywords: coronavirus therapeutics; antiviral target; host-directed antivirals; immunomodulation; diagnostics; prevention; antiviral resistance; AI-driven drug discovery

(This special issue belongs to the Section Coronaviruses)

Veterinary Virology: Unraveling Host–Pathogen Interactions for Animal Health

edited by

Muhammad Jasim Uddin

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3081 | Submission Open

Keywords: veterinary virology; host–pathogen interactions; viral replication and immune evasion; zoonotic viruses; One Health; vaccine and therapeutic development; molecular virology and genomics; emerging and re-emerging viral pathogens or diseases; animal health and welfare; high-throughput or deep sequencing; outbreak prevention and control; food security

(This special issue belongs to the Section Animal Viruses)

The Entry and Fusion of Enveloped Virus

edited by

Tsutomu Murakami

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3037 | Submission Open

Keywords: enveloped virus; entry; attachment; virus binding; membrane fusion; internalization; endocytosis; uncoating; intracellular trafficking; nuclear import; receptor; carbohydrates; antiviral; neutralizing antibody; vaccine

(This special issue belongs to the Section General Virology)

Coronaviruses: Variants, Antivirals, and Vaccination

edited by

Cheng-Wen Lin

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2770 | Submission Open

Keywords: coronavirus variants; SARS-CoV-2 evolution; antivirals; vaccination; immune response; global health; viral pathogenesis; public health preparedness; host genomics; monoclonal antibodies

(This special issue belongs to the Section Coronaviruses)

Unraveling Human Herpesviruses: From Molecular Mechanisms to Antiviral Approaches

edited by

Christopher B. Whitehurst

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2458 | Submission Open

Keywords: human herpesviruses; post-translational modifications; epigenetics; cancer; molecular mechanisms; antivirals; protein interactions

(This special issue belongs to the Section Human Virology and Viral Diseases)

3D Models in Viral Pathogenesis

edited by

David C. Bloom

Leonardo D'Aiuto

and Elizabeth Fortunato

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2136 | Submission Open

Keywords: organoids; viral pathogenesis; mini-brains; 3D culture; viruses; in vitro models

(This special issue belongs to the Section General Virology)

Common Pathogenic Mechanisms of Plant Viruses

edited by

Yen-Wen Kuo

and Jun Jiang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1029 | Submission Open

Keywords: plant viruses; viral pathogenicity; host–virus interactions; viral replication; virus movement; suppression of RNA silencing; plant immunity; conserved mechanisms; molecular virology

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Immune Evasion and Viral Carcinogenesis

edited by

Christoph Weigel

and Tuan L. Phan

submission deadline 30 Sep 2026 | 1 articles | Viewed by 682 | Submission Open

Keywords: viral oncogenesis; viral carcinogenesis; immune evasion; immune surveillance; oncogenic viruses; immunosuppression; host-pathogen interactions

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Innate Immune Sensing of Viruses

edited by Zi Li

submission deadline 30 Sep 2026 | Viewed by 517 | Submission Open

Keywords: innate immunity; viral sensing; pattern recognition receptors (PRRs); damage-associated molecular patterns (DAMPs); interferon response; inflammasome activation; viral immune evasion; antiviral defense; trained immunity; immunometabolism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Neuropathogenesis in HIV Infection: Mechanisms and Reservoirs

edited by Rebecca T. Veenhuis

submission deadline 30 Sep 2026 | Viewed by 426 | Submission Open

Keywords: HIV-associated neuroinflammation; HIV reservoirs; HIV-associated neuropathogenesis; HIV-associated comorbidities

(This special issue belongs to the Section Human Virology and Viral Diseases)

Alphavirus Structural Dynamics and Host–Cell Entry: Structure-Guided Therapeutic and Vaccine Development

edited by

Qibin Geng

submission deadline 30 Sep 2026 | Viewed by 393 | Submission Open

Keywords: alphavirus virion architecture; cryo-EM/cryo-ET; E1/E2 glycoproteins; receptor recognition and tropism; membrane fusion; structural dynamics; nsP replication complexes; structure-guided antiviral discovery; neutralizing antibodies/nanobodies; alphavirus-induced arthritis

(This special issue belongs to the Section Animal Viruses)

Viruses Associated with Gastroenteritis: 2nd Edition

edited by

Celso Cunha

and

Claudia Istrate

submission deadline 30 Sep 2026 | Viewed by 366 | Submission Open

Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Re-Emergence of Yellow Fever Virus

edited by Rosemary Sang

submission deadline 30 Sep 2026 | Viewed by 351 | Submission Open

Keywords: yellow fever virus; Orthoflavivirus; mosquito-borne transmission; viral evolution; outbreak expansion; vaccination challenges; molecular epidemiology; control strategies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Filoviruses: Ebola and Marburg—Virus–Host Interactions: New Insights into Viral Pathogenesis and Therapeutic Advances

edited by

Asuka Nanbo

submission deadline 30 Sep 2026 | Viewed by 350 | Submission Open

Keywords: virus–host interactions; viral infection mechanisms; viral pathogenesis; therapeutic strategies; vaccine development; advanced experimental technologies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Imaging Neurotropic Viruses

edited by

Elena Criscuolo

and

Salla Mattola

submission deadline 30 Sep 2026 | Viewed by 341 | Submission Open

Keywords: neurotropic viruses; neuroinvasion; immune evasion; host–virus interactions; neuronal models; organoids; live-cell microscopy; microfuidics

(This special issue belongs to the Section General Virology)

Plant Viruses and Their Vectors: Epidemiology, Control, and Diagnostics

edited by

Beata Hasiów-Jaroszewska

and

Matthaios M. Mathioudakis

submission deadline 30 Sep 2026 | Viewed by 290 | Submission Open

Keywords: epidemiology; diagnostics tools; virus-vector-host interactions; genetic diversity

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Zoonotic and Vector-Borne Viral Diseases: 2nd Edition

edited by

Nariman Shahhosseini

submission deadline 1 Oct 2026 | 4 articles | Viewed by 5839 | Submission Open

Keywords: vector-borne viral diseases (VBVDs); vector–host–pathogen interactions; emerging and re-emerging; zoonotic diseases; vectors or reservoirs; vaccine development, and prevention and control measures; One Health

(This special issue belongs to the Section Animal Viruses)

Viruses 2026—New Horizons in Virology

edited by

Eric O. Freed

and

Albert Bosch

submission deadline 1 Oct 2026 | 3 articles | Viewed by 4768 | Submission Open

Keywords: virus; replication; assembly; pathogenesis; outbreak; molecular biology; cell biology; public health; structural biology

(This special issue belongs to the Section General Virology)

Epigenetic Modifications in Viral Infections 2026

edited by

Matloob Husain

and

Farjana Ahmed

submission deadline 15 Oct 2026 | Viewed by 320 | Submission Open

Keywords: viral pathogenesis; virus–host interaction; epigenetic modifications; acetylation; methylation; proteomics; genomics

(This special issue belongs to the Section General Virology)

Enteric Viruses in Environment and Humans: Identification, Surveillance and Control

edited by

Rita De Cássia Compagnoli Carmona

and Maria Inês Zanoli Sato

submission deadline 30 Oct 2026 | 9 articles | Viewed by 10865 | Submission Open

Keywords: enteric viruses; wastewater-based epidemiology; human-based epidemiology; One Health

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in Animal Influenza Virus Research 2026

edited by

Jansen Araujo

submission deadline 30 Oct 2026 | 4 articles | Viewed by 9074 | Submission Open

Keywords: animal influenza viruses; avian influenza virus; H5N1; viral evolution; viral reassortment; zoonotic potential transmission; diagnostics advances; molecular epidemiology and vaccine development

(This special issue belongs to the Section Animal Viruses)

Advances in Endemic and Emerging Viral Diseases in Livestock: 2nd Edition

edited by

Fernando Vicosa Bauermann

and

Mayara Maggioli

submission deadline 30 Oct 2026 | 2 articles | Viewed by 3260 | Submission Open

Keywords: veterinary virology; livestock; ruminants; swine; vaccines

(This special issue belongs to the Section Animal Viruses)

Tick-Borne Viruses 2026

edited by

Pat Nuttall

submission deadline 31 Oct 2026 | 8 articles | Viewed by 12425 | Submission Open

Keywords: tick-borne viruses; vector-borne pathogens; virus–tick–host interactions; saliva-assisted transmission; tick exosomes; tick antiviral mechanisms; virus evolution; surveillance

(This special issue belongs to the Section General Virology)

Influenza and Other Respiratory Viruses: Prevention, Diagnosis, Treatment: 3rd Edition

edited by

Eric Yager

submission deadline 31 Oct 2026 | 4 articles | Viewed by 7075 | Submission Open

Keywords: influenza; adenovirus; coronoavirus; respiratory syncytial virus; rhinovirus; respiratory virus; antiviral strategies; epidemiology; diagnosis; treatment; vaccination; surveillance; vaccine development

(This special issue belongs to the Section Animal Viruses)

New Findings in Animal Biosecurity Related to Viral Diseases

edited by

Claude Saegerman

and Jean-Pierre Vaillancourt

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5120 | Submission Open

Keywords: viruses; animal; biosecurity; evaluation; communication; needs; cost–benefit analysis; behaviour change

(This special issue belongs to the Section Animal Viruses)

Bacteriophages and Biofilms 2026

edited by

Bartłomiej Grygorcewicz

submission deadline 31 Oct 2026 | 2 articles | Viewed by 4352 | Submission Open

Keywords: bacteriophages; phage therapy; biofilms; phage–biofilm interaction; depolymerases; antibiofilm agents; phage engineering; phage resistance; combination therapy; microbial ecology

(This special issue belongs to the Section Bacterial Viruses)

Early ART Initiation: Impacts on Viral Dynamics and Clinical Outcomes

edited by

Alessandra Vergori

Andrea De Vito

and

Vincenzo Malagnino

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3087 | Submission Open

Keywords: early antiretroviral therapy; HIV viral dynamics; immune recovery; viral reservoir; clinical outcomes; HIV transmission

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Preparation for the Next Potential Pandemic—Chikungunya, Dengue, Zika and Other Viruses 2026

edited by

Zoltan Vajo

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2659 | Submission Open

Keywords: chikungunya; dengue; zika; next pandemic; epidemiology; pharmaceutics; immunology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses: 2nd Edition

edited by

Sasan Fereidouni

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2540 | Submission Open

Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission

(This special issue belongs to the Section Animal Viruses)

Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition

edited by

Grigoris Zoidis

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2063 | Submission Open

Keywords: medicinal chemistry of anti-HCV, anti-HBV and anti-flavivirus agents; synthesis; structure activity relationships (SAR); antiviral drug discovery; HBV; HCV; Dengue (DENV); Yellow Fever (YFV); West Nile (WNV); Zika (ZIKV); mechanism of action; drug targets; in silico studies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Signaling Pathways in Viral Infection and Antiviral Immunity 2026

edited by

Malathi Krishnamurthy

Praveen Manivannan

, Shelby Clark and Barkha Ramnani

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1879 | Submission Open

Keywords: innate immune signaling pathways; antiviral signaling; interferon signaling; cytokine induction and inflammation; host–virus interactions; cell death pathways; autophagy; stress response pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Molecular Biomarkers for Viral Infection, 2nd Edition

edited by

Paulina Niedźwiedzka-Rystwej

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1726 | Submission Open

Keywords: molecular biomarkers; viral infections; metabolism

(This special issue belongs to the Section General Virology)

Interplay Between Influenza Virus and Host Factors, 2nd Edition

edited by

Matloob Husain

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1501 | Submission Open

Keywords: influenza virus; host factors; proviral host factors; antiviral host factors; host adaptation; virus entry; virus assembly; virus release; innate antiviral response; interferon-stimulated genes; post-translational protein modifications

(This special issue belongs to the Section Animal Viruses)

70 Years of Rhinoviruses: From the Common Cold to Complex Pathogens

edited by

Katarzyna Niespodziana

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1456 | Submission Open

Keywords: rhinovirus (RV); asthma; COPD; airway; infection; immunity; diversity; therapy; vaccine; history

(This special issue belongs to the Section Human Virology and Viral Diseases)

Giant, Jumbo and Mega Phages

edited by

Julie Thomas

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1437 | Submission Open

Keywords: long-genome phage; giant phage; jumbo phage; mega phage; genomes; structure/assembly; infection strategies; ecology; evolution; applications

(This special issue belongs to the Section Bacterial Viruses)

Hantaviruses and Their Hosts

edited by Hiroaki Kariwa and

Kumiko Yoshimatsu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1023 | Submission Open

Keywords: hantavirus; hosts; rodents; shrews; bats; moles; virus–host interaction

(This special issue belongs to the Section Animal Viruses)

Bacteriophage-Based Biocontrol in Agriculture, 3rd Edition

edited by

Elena G. Biosca

and

María Belén Álvarez Ortega

submission deadline 31 Oct 2026 | 1 articles | Viewed by 830 | Submission Open

Keywords: phage-therapy; biocontrol; phytopathogenic bacteria; bioproduction; field application

(This special issue belongs to the Section Bacterial Viruses)

Arbovirus Diagnosis

edited by Lakshmanane Premkumar and Jesse Waggoner

submission deadline 31 Oct 2026 | Viewed by 589 | Submission Open

Keywords: arboviruses; molecular tests; serology; multiplex assays; diagnostic methods; surveillance; high-throughput assays; point-of-care tests

(This special issue belongs to the Section Human Virology and Viral Diseases)

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