Increased Plasma Cell-Free DNA Level during HTNV Infection: Correlation with Disease Severity and Virus Load
AbstractCell-free DNA (cf-DNA) in blood represents a promising DNA damage response triggered by virus infection or trauma, tumor, etc. Hantavirus primarily causes two diseases: haemorrhagic fever with renal syndrome (HFRS) and Hantavirus cardiopulmonary syndrome (HCPS), depending on different Hantavirus species. The aim of this study was to evaluate plasma cf-DNA levels in acute phase of HFRS, and to correlate plasma cf-DNA with disease severity and plasma Hanttan virus (HTNV) load. We observed the appearance of cf-DNA in 166 plasma samples from 76 HFRS patients: the plasma cf-DNA levels peaked at the hypotensive stage of HFRS, and then decreased gradually. Until the diuretic stage, there was no significant difference in plasma cf-DNA level between patients and the healthy control. Exclusively in the febrile/hypotensive stage, the plasma cf-DNA levels of severe/critical patients were higher than those of the mild/moderate group. Moreover, the plasma cf-DNA value in the early stage of HFRS was correlated with HTNV load and disease severity. In most of the patients, plasma cf-DNA displayed a low-molecular weight appearance, corresponding to the size of apoptotic DNA. In conclusion, the plasma cf-DNA levels were dynamically elevated during HFRS, and correlated with disease severity, which suggests that plasma cf-DNA may be a potential biomarker for the pathogenesis and prognosis of HFRS. View Full-Text
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Yi, J.; Zhang, Y.; Zhang, Y.; Ma, Y.; Zhang, C.; Li, Q.; Liu, B.; Liu, Z.; Liu, J.; Zhang, X.; Zhuang, R.; Jin, B. Increased Plasma Cell-Free DNA Level during HTNV Infection: Correlation with Disease Severity and Virus Load. Viruses 2014, 6, 2723-2734.
Yi J, Zhang Y, Zhang Y, Ma Y, Zhang C, Li Q, Liu B, Liu Z, Liu J, Zhang X, Zhuang R, Jin B. Increased Plasma Cell-Free DNA Level during HTNV Infection: Correlation with Disease Severity and Virus Load. Viruses. 2014; 6(7):2723-2734.Chicago/Turabian Style
Yi, Jing; Zhang, Yun; Zhang, Yusi; Ma, Ying; Zhang, Chunmei; Li, Qi; Liu, Bei; Liu, Zhijia; Liu, Jiayun; Zhang, Xianqing; Zhuang, Ran; Jin, Boquan. 2014. "Increased Plasma Cell-Free DNA Level during HTNV Infection: Correlation with Disease Severity and Virus Load." Viruses 6, no. 7: 2723-2734.