Special Issue "Phytoalexins: Current Progress and Future Prospects"


A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: closed (30 April 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Philippe Jeandet
Laboratory of Stress, Defenses and Plant Reproduction, U.R.V.V.C., UPRES EA 4707, Faculty of Sciences, University of Reims, PO Box. 1039, 51687 Reims cedex 02, France
Website: http://www.mdpi.com/files/misc/cv-prof-dr-philippe-jeandet.pdf
E-Mail: philippe.jeandet@univ-reims.fr
Phone: +33 3 26 91 33 41
Interests: plant defense mechanisms; particularly study of the grapevine (Vitis spp.) phytoalexins (resveratrol and derivatives): chemical synthesis; biosynthesis; chemical analyses; phytoalexin metabolism by Botrytis cinerea; antifungal activity and molecular engineering of resveratrol in plants and microbial cells

Special Issue Information

Dear Colleagues,

Phytoalexins are antimicrobial substances of low molecular weight produced by plants in response to infection or stress, which form part of their active defense mechanisms. It is now clear that phytoalexins exhibit toxicity across much of the biological spectrum, prokaryotic and eukaryotic. Starting in the 1950s, research on phytoalexins has begun with biochemistry and bio-organic chemistry, resulting in the determination of their structure, their biological activity as well as mechanisms of their synthesis and their catabolism by microorganisms. Elucidation of the biosynthesis of numerous phytoalexins has also permitted the use of molecular biology tools for the exploration of the genes encoding enzymes of their synthesis pathways and their regulators. This has led to potential applications for increasing plant resistance to diseases. Phytoalexins display an enormous diversity belonging to various chemical families such as isoflavones, isoflavanones, pterocarpans, isoflavans, flavanones, coumestans, furanoacetylenes, phenylpropanoids, steroid glycoalkaloids, norsesquiterpenoids/sesquiterpenoids, coumarins, diterpenes, ent-kaurane-related diterpenoids, acidic sesquiterpenoids, 3-deoxyanthocyanidins, naphthaldehydes, indoles and stilbenes.
Research papers dealing with all aspects of phytoalexins, including structure elucidation; chemical synthesis; methods for phytoalexin analysis in plant extracts or biological fluids; biosynthesis studies including modulation of phytoalexin synthesis; engineering of phytoalexin biochemical pathways in plants and microbes; biological activities; structure/activity relationships; phytoalexin metabolism in planta and by micro-organisms; roles and ATP Binding Cassette (ABC) transporters or Multi-Drugs Efflux (MDE) transporters are welcome for inclusion in this Special Issue of Molecules. Review articles, particularly those dealing with the themes mentioned above are also particularly welcome for inclusion.

Prof. Dr. Philippe Jeandet
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

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  • phytoalexin structure elucidation
  • chemical synthesis
  • methods for phytoalexin analysis
  • biosynthetic studies and modulation of phytoalexin biosynthesis
  • molecular engineering in plants and microbes / applications
  • biological activities
  • structure/activity relationships
  • plant metabolism
  • fungal metabolism
  • transport mechanisms
  • applications

Published Papers (10 papers)

by , , , , , ,  and
Molecules 2014, 19(8), 10877-10897; doi:10.3390/molecules190810877
Received: 30 April 2014; in revised form: 17 July 2014 / Accepted: 18 July 2014 / Published: 25 July 2014
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by , , , , ,  and
Molecules 2014, 19(8), 10717-10732; doi:10.3390/molecules190810717
Received: 8 May 2014; in revised form: 9 July 2014 / Accepted: 10 July 2014 / Published: 24 July 2014
Show/Hide Abstract | PDF Full-text (1167 KB) | Supplementary Files

by , , ,  and
Molecules 2014, 19(7), 10587-10600; doi:10.3390/molecules190710587
Received: 4 May 2014; in revised form: 1 July 2014 / Accepted: 16 July 2014 / Published: 21 July 2014
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by  and
Molecules 2014, 19(7), 9114-9133; doi:10.3390/molecules19079114
Received: 19 May 2014; in revised form: 26 June 2014 / Accepted: 26 June 2014 / Published: 30 June 2014
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by , , ,  and
Molecules 2014, 19(6), 7850-7868; doi:10.3390/molecules19067850
Received: 29 April 2014; in revised form: 27 May 2014 / Accepted: 28 May 2014 / Published: 11 June 2014
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by , , , ,  and
Molecules 2014, 19(6), 7679-7688; doi:10.3390/molecules19067679
Received: 25 April 2014; in revised form: 3 June 2014 / Accepted: 5 June 2014 / Published: 10 June 2014
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by , , , , ,  and
Molecules 2014, 19(6), 7480-7496; doi:10.3390/molecules19067480
Received: 15 April 2014; in revised form: 29 May 2014 / Accepted: 30 May 2014 / Published: 6 June 2014
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by , ,  and
Molecules 2014, 19(6), 7327-7340; doi:10.3390/molecules19067327
Received: 16 April 2014; in revised form: 23 May 2014 / Accepted: 23 May 2014 / Published: 5 June 2014
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by , , , ,  and
Molecules 2014, 19(4), 3988-4005; doi:10.3390/molecules19043988
Received: 7 January 2014; in revised form: 5 March 2014 / Accepted: 5 March 2014 / Published: 2 April 2014
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by , , ,  and
Molecules 2014, 19(2), 1432-1458; doi:10.3390/molecules19021432
Received: 10 December 2013; in revised form: 2 January 2014 / Accepted: 13 January 2014 / Published: 27 January 2014
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type Paper: Editorial
Title: Deciphering the Roles of Phytoalexins in Plant-Microorganism Interactions and in Human Health
Authors: Philippe Jeandet, Claire Hébrard, Sylvain Cordelier, Marie-Alice Deville, Stéphan Dorey, Aziz Aziz, and Jérôme Crouzet
Abstract: Phytoalexins are low molecular weight antimicrobial compounds that are produced by plants as a response to biotic and abiotic stresses. As such they take part in an intricate defence system which enables plants to control invading microorganisms. In the editorial of this phytoalexin special issue we present the key features of this diverse group of molecules, namely their chemical structures, biosynthesis, regulatory mechanisms, biological activities, metabolism and molecular engineering

Last update: 10 July 2014

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