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Molecules 2014, 19(6), 7679-7688; doi:10.3390/molecules19067679

Antimicrobial Activity of Resveratrol Analogues

1
Université de Bourgogne, UMR1347 Agroécologie, ERL CNRS 6300, BP 86510, 21065 Dijon Cedex, France
2
INRA, UMR1347 Agroécologie, ERL CNRS 6300, BP 86510, 21065 Dijon Cedex, France
3
Welience, Maison Régionale de L'Innovation, 64 A rue de Sully, CS 77124, 21071 Dijon Cedex, France
4
Institut de Chimie Moléculaire de l'Université de Bourgogne, ICMUB-UMR CNRS 6302, 9 Avenue Alain Savary, 21000 Dijon, France
Present address: Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, Campus du Moulin de la House, BP 1039, F-51687 Reims Cedex, France.
*
Author to whom correspondence should be addressed.
Received: 25 April 2014 / Revised: 3 June 2014 / Accepted: 5 June 2014 / Published: 10 June 2014
(This article belongs to the Special Issue Phytoalexins: Current Progress and Future Prospects)
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Abstract

Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew). Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold). The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups) and antimicrobial activity. View Full-Text
Keywords: resveratrol; stilbenes; grapevine; downy mildew; grey mold; Plasmopara viticola; Botrytis cinerea resveratrol; stilbenes; grapevine; downy mildew; grey mold; Plasmopara viticola; Botrytis cinerea
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MDPI and ACS Style

Chalal, M.; Klinguer, A.; Echairi, A.; Meunier, P.; Vervandier-Fasseur, D.; Adrian, M. Antimicrobial Activity of Resveratrol Analogues. Molecules 2014, 19, 7679-7688.

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