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Deciphering the Role of Phytoalexins in Plant-Microorganism Interactions and Human Health
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Molecules 2015, 20(1), 24-34; doi:10.3390/molecules20010024

EDTA a Novel Inducer of Pisatin, a Phytoalexin Indicator of the Non-Host Resistance in Peas

Department of Plant Pathology, Washington State University, Pullman, WA 99164-6430, USA
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Author to whom correspondence should be addressed.
Academic Editor: Philippe Jeandet
Received: 11 October 2014 / Accepted: 17 December 2014 / Published: 23 December 2014
(This article belongs to the Special Issue Phytoalexins: Current Progress and Future Prospects)
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Abstract

Pea pod endocarp suppresses the growth of an inappropriate fungus or non-pathogen by generating a “non-host resistance response” that completely suppresses growth of the challenging fungus within 6 h. Most of the components of this resistance response including pisatin production can be elicited by an extensive number of both biotic and abiotic inducers. Thus this phytoalexin serves as an indicator to be used in evaluating the chemical properties of inducers that can initiate the resistance response. Many of the pisatin inducers are reported to interact with DNA and potentially cause DNA damage. Here we propose that EDTA (ethylenediaminetetraacetic acid) is an elicitor to evoke non-host resistance in plants. EDTA is manufactured as a chelating agent, however at low concentration it is a strong elicitor, inducing the phytoalexin pisatin, cellular DNA damage and defense-responsive genes. It is capable of activating complete resistance in peas against a pea pathogen. Since there is also an accompanying fragmentation of pea DNA and alteration in the size of pea nuclei, the potential biochemical insult as a metal chelator may not be its primary action. The potential effects of EDTA on the structure of DNA within pea chromatin may assist the transcription of plant defense genes. View Full-Text
Keywords: DNA damage; pathogenesis-related genes; defensins; DNA-specific; disease resistance DNA damage; pathogenesis-related genes; defensins; DNA-specific; disease resistance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hadwiger, L.A.; Tanaka, K. EDTA a Novel Inducer of Pisatin, a Phytoalexin Indicator of the Non-Host Resistance in Peas. Molecules 2015, 20, 24-34.

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