Special Issue "Chitin and Chitosan Derivatives: Biological Activities and Application"
Deadline for manuscript submissions: closed (15 October 2017)
Prof. Dr. Már Másson
Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavík, Iceland
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Interests: chitosan and chitosan conjugates; synthesis; structure activity relationship (SAR); spectroscopy; antimicrobial chitosan conjugates and natural compound derivatives; photochemistry; NMR analysis; nanomedicine; nanoparticles; regenerative medicine; antimicrobial activity; absorption enhancers; photodynamic therapy; cancer therapy; mathematical modeling and design of experiment (DOE)
Chitin and chitosan (poly β-1,4 linked D-glucosamine and N-acetyl-D-glucosamine) are biocompatible biopolymers with some unique biological properties. They have found applications in a number of fields, including medicine, pharmaceuticals, food processing, cosmetics, and agriculture. The use of these biopolymers is growing and research activities continue to increase; however, there are certain limitations for the use unmodified chitin and chitosan, mainly because the structural variation of the unmodified polymer is restricted to changes in the degree of N-acetylation and the molecular weight. Thus, there is more focus on the chemical modification of chitin and chitosan to make chitosan derivatives (conjugates). This promises to significantly expand utility in various fields, where these biopolymers have been used, and will also lead to novel applications. Many types of functional groups, including lipophilic and charged groups, have been introduced in order to enhance the bioactivity or desired physicochemical properties. Bioactive moieties, such as drugs, natural compounds, and various biomacromolecules, can be conjugated to the polymer backbone to give new types of materials that can be designed to function as drug delivery systems, components for constructing nanoparticles that can target certain cell types, imaging agents, and materials that have been tailored for certain regenerative properties. Chemically-reactive groups can also be introduced to promote polymerization or non-covalent bonding between polymer chains. These materials can be used to prepare stable bioactive coatings, hydrogels, and other types of complex biomaterials. To fully reach the potential of this new field, there are number of challenges that researchers must overcome. There is still a great deal of room to develop new efficient synthesis and grafting procedures. In order to further the understanding of the structural activity and structure property relationships, improved tools and methods for accurate structural and physicochemical characterization will be essential. A better understanding of how bioactivity can be improved, without increasing the potential for of adverse effects, is needed. In response to these developments, and in order to encourage researchers from different backgrounds to share the results, Molecules is launching this Special Issue. Topics can include, but are not limited to:
- Enzyme Catalyzed Reactions
- Reaction Mechanism
- Structure Characterization (including NMR)
- Physicochemical characteristics
- Structure property relationship
- Antimicrobial properties
- Anticancer properties
- Regenerative properties
- Structure Activity Relationship
- Drug Delivery
- Gene Delivery
- Composite materials
Prof. Dr. Már Másson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Chitosan conjugates
- Chitosan derivatives
- Chitin derivatives
- Medicina chemistry
- Polymer chemistry
- Pestov, A.; Bratskaya, S. Chitosan and Its Derivatives as Highly Efficient Polymer Ligands. Molecules 2016, 21, 330.
- Ramirez-Estrada, K.; Vidal-Limon, H.; Hidalgo, D.; Moyano, E.; Golenioswki, M.; Cusidó, R.M.; Palazon, J. Elicitation, an Effective Strategy for the Biotechnological Production of Bioactive High-Added Value Compounds in Plant Cell Factories. Molecules 2016, 21, 182.
- Ruocco, N.; Costantini, S.; Guariniello, S.; Costantini, M. Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential. Molecules 2016, 21, 551.
- Ohkawa, K. Nanofibers of Cellulose and Its Derivatives Fabricated Using Direct Electrospinning. Molecules 2015, 20, 9139-9154.
- Ifuku, S. Chitin and Chitosan Nanofibers: Preparation and Chemical Modifications. Molecules 2014, 19, 18367-18380.