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Molecules 2018, 23(2), 229; https://doi.org/10.3390/molecules23020229

Chemical Modification of Chitosan for Efficient Vaccine Delivery

1
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
2
Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China
3
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China
4
Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China
5
Department of Animal Science, College of Agriculture Science, Yanbian University, Yanji, Jilin 133002, China
6
Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 22 November 2017 / Revised: 1 January 2018 / Accepted: 11 January 2018 / Published: 25 January 2018
View Full-Text   |   Download PDF [12318 KB, uploaded 25 January 2018]   |  

Abstract

Chitosan, which exhibits good biocompatibility, safety, microbial degradation and other excellent performances, has found application in all walks of life. In the field of medicine, usage of chitosan for the delivery of vaccine is favored by a wide range of researchers. However, due to its own natural limitations, its application has been constrained to the beginning of study. In order to improve the applicability for vaccine delivery, researchers have carried out various chemical modifications of chitosan. This review summarizes a variety of modification methods and applications of chitosan and its derivatives in the field of vaccine delivery. View Full-Text
Keywords: chitosan; chitosan derivatives; vaccine; DNA; chemical modification chitosan; chitosan derivatives; vaccine; DNA; chemical modification
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Xing, L.; Fan, Y.-T.; Zhou, T.-J.; Gong, J.-H.; Cui, L.-H.; Cho, K.-H.; Choi, Y.-J.; Jiang, H.-L.; Cho, C.-S. Chemical Modification of Chitosan for Efficient Vaccine Delivery. Molecules 2018, 23, 229.

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