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Molecules 2018, 23(6), 1429; https://doi.org/10.3390/molecules23061429

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

1
Yenepoya Research Center, Yenepoya (Deemed to Be University), Deralakatte, Mangalore 575018, Karnataka, India
2
Division of Bioengineering, Incheon National University, Incheon 22012, Korea
3
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India
4
Marine Bioprocess Research Centre and Department of Marine Bio-Convergence Science, Pukyong National University, Sinseon-ro 365, Nam-gu, Busan 608739, Korea
5
Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha University, Poonamallee High Road, Chennai 600077, India
*
Authors to whom correspondence should be addressed.
Academic Editor: Már Másson
Received: 19 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 12 June 2018
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Abstract

Silver nanoparticles (AgNPs) are gaining a great deal of attention in biomedical applications due to their unique physicochemical properties. In this study, green synthesis of AgNPs was developed using seaweed polysaccharide fucoidan. The AgNPs were further coated with chitosan to form an electrolyte complex on the surface. The developed chitosan–fucoidan complex-coated AgNPs were characterized using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). FT-IR results suggested strong polyelectrolyte complexation between fucoidan and chitosan. The developed chitosan–fucoidan complex-coated AgNPs significantly inhibited microbial growth. Moreover, the AgNPs showed efficient anticancer activity in human cervical cancer cells (HeLa). This study demonstrated that chitosan–fucoidan complex-coated AgNPs hold high potential for food and cosmeceutical applications. View Full-Text
Keywords: chitosan; fucoidan; silver nanoparticles; antimicrobial activity chitosan; fucoidan; silver nanoparticles; antimicrobial activity
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Venkatesan, J.; Singh, S.K.; Anil, S.; Kim, S.-K.; Shim, M.S. Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating. Molecules 2018, 23, 1429.

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