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Molecules 2017, 22(10), 1662; doi:10.3390/molecules22101662

Versatile Chemical Derivatizations to Design Glycol Chitosan-Based Drug Carriers

1
Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical College, Guro Hospital, Seoul 08308, Korea
2
Department of Food Science and Engineering, Ewha Womans University, Seoul 03760, Korea
3
Department of Systems Biotechnology, College of Biotechnology and Natural Resources, Chung-Ang University, Gyeonggi-do 17546, Korea
*
Authors to whom correspondence should be addressed.
Received: 8 August 2017 / Revised: 26 September 2017 / Accepted: 2 October 2017 / Published: 5 October 2017
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Abstract

Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy. View Full-Text
Keywords: glycol chitosan; chemical derivatizations; nanoparticles; drug carriers; disease therapy glycol chitosan; chemical derivatizations; nanoparticles; drug carriers; disease therapy
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Kim, S.E.; Kim, H.-J.; Rhee, J.-K.; Park, K. Versatile Chemical Derivatizations to Design Glycol Chitosan-Based Drug Carriers. Molecules 2017, 22, 1662.

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