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Molecules 2017, 22(11), 1976; doi:10.3390/molecules22111976

Development of Gallic Acid-Modified Hydrogels Using Interpenetrating Chitosan Network and Evaluation of Their Antioxidant Activity

1
Nuclear Chemistry Research Division, Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseong-gu, Daejeon 34057, Korea
2
Department of Chemistry, Chosun University, Gwangju 61452, Korea
3
Department of Natural Sciences, Caraga State University, Butuan City 8600, Philippines
4
Department of Chemistry, Dankook University, 119, Dandae-ro, Chungnam 31116, Korea
5
Department of Biomedical Engineering, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea
These authors equally contributed to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 October 2017 / Revised: 4 November 2017 / Accepted: 13 November 2017 / Published: 15 November 2017
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Abstract

In this work, antioxidant hydrogels were prepared by the construction of an interpenetrating chitosan network and functionalization with gallic acid. The poly(2-hydroxyethyl methacrylate) p(HEMA)-based hydrogels were first synthesized and subsequently surface-modified with an interpenetrating polymer network (IPN) structure prepared with methacrylamide chitosan via free radical polymerization. The resulting chitosan-IPN hydrogels were surface-functionalized with gallic acid through an amide coupling reaction, which afforded the antioxidant hydrogels. Notably, gallic-acid-modified hydrogels based on a longer chitosan backbone exhibited superior antioxidant activity than their counterpart with a shorter chitosan moiety; this correlated to the amount of gallic acid attached to the chitosan backbone. Moreover, the surface contact angles of the chitosan-modified hydrogels decreased, indicating that surface functionalization of the hydrogels with chitosan-IPN increased the wettability because of the presence of the hydrophilic chitosan network chain. Our study indicates that chitosan-IPN hydrogels may facilitate the development of applications in biomedical devices and ophthalmic materials. View Full-Text
Keywords: chitosan; IPN; hydrogels; antioxidant activity; gallic acid chitosan; IPN; hydrogels; antioxidant activity; gallic acid
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Kang, B.; Vales, T.P.; Cho, B.-K.; Kim, J.-K.; Kim, H.-J. Development of Gallic Acid-Modified Hydrogels Using Interpenetrating Chitosan Network and Evaluation of Their Antioxidant Activity. Molecules 2017, 22, 1976.

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