Int. J. Mol. Sci. 2012, 13(12), 15496-15509; doi:10.3390/ijms131215496
Review

Identification of kakusei, a Nuclear Non-Coding RNA, as an Immediate Early Gene from the Honeybee, and Its Application for Neuroethological Study

1,* email, 2email, 2email and 2email
Received: 29 October 2012; in revised form: 16 November 2012 / Accepted: 19 November 2012 / Published: 22 November 2012
(This article belongs to the Special Issue Non-Coding RNAs 2012)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The honeybee is a social insect that exhibits various social behaviors. To elucidate the neural basis of honeybee behavior, we detected neural activity in freely-moving honeybee workers using an immediate early gene (IEG) that is expressed in a neural activity-dependent manner. In European honeybees (Apis mellifera), we identified a novel nuclear non-coding RNA, termed kakusei, as the first insect IEG, and revealed the neural activity pattern in foragers. In addition, we isolated a homologue of kakusei, termed Acks, from the Japanese honeybee (Apis cerana), and detected active neurons in workers fighting with the giant hornet.
Keywords: honeybee; kakusei; immediate early gene; insect; brain; non-coding RNA; foraging behavior; dance communication; Japanese honeybee; hot defensive bee ball formation
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MDPI and ACS Style

Kiya, T.; Ugajin, A.; Kunieda, T.; Kubo, T. Identification of kakusei, a Nuclear Non-Coding RNA, as an Immediate Early Gene from the Honeybee, and Its Application for Neuroethological Study. Int. J. Mol. Sci. 2012, 13, 15496-15509.

AMA Style

Kiya T, Ugajin A, Kunieda T, Kubo T. Identification of kakusei, a Nuclear Non-Coding RNA, as an Immediate Early Gene from the Honeybee, and Its Application for Neuroethological Study. International Journal of Molecular Sciences. 2012; 13(12):15496-15509.

Chicago/Turabian Style

Kiya, Taketoshi; Ugajin, Atsushi; Kunieda, Takekazu; Kubo, Takeo. 2012. "Identification of kakusei, a Nuclear Non-Coding RNA, as an Immediate Early Gene from the Honeybee, and Its Application for Neuroethological Study." Int. J. Mol. Sci. 13, no. 12: 15496-15509.

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