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Blood microRNAs in Low or No Risk Ischemic Stroke Patients
Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore
Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia
Department of Biochemistry, Faculty of Medicine, MAHSA University College, 59100 Kuala Lumpur, Malaysia
Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3800, Australia
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 November 2012; in revised form: 11 December 2012 / Accepted: 17 January 2013 / Published: 22 January 2013
Abstract: Ischemic stroke is a multi-factorial disease where some patients present themselves with little or no risk factors. Blood microRNA expression profiles are becoming useful in the diagnosis and prognosis of human diseases. We therefore investigated the blood microRNA profiles in young stroke patients who presented with minimal or absence of risk factors for stroke such as type 2 diabetes, dyslipidemia and hypertension. Blood microRNA profiles from these patients varied with stroke subtypes as well as different functional outcomes (based on modified Rankin Score). These microRNAs have been shown to target genes that are involved in stroke pathogenesis. The findings from our study suggest that molecular mechanisms in stroke pathogenesis involving low or no risk ischemic stroke patients could differ substantially from those with pre-existing risk factors.
Keywords: stroke; microRNA; etiology; modified Rankin Score
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Tan, J.R.; Tan, K.S.; Koo, Y.X.; Yong, F.L.; Wang, C.W.; Armugam, A.; Jeyaseelan, K. Blood microRNAs in Low or No Risk Ischemic Stroke Patients. Int. J. Mol. Sci. 2013, 14, 2072-2084.
Tan JR, Tan KS, Koo YX, Yong FL, Wang CW, Armugam A, Jeyaseelan K. Blood microRNAs in Low or No Risk Ischemic Stroke Patients. International Journal of Molecular Sciences. 2013; 14(1):2072-2084.
Tan, Jun R.; Tan, Kay S.; Koo, Yu X.; Yong, Fung L.; Wang, Chee W.; Armugam, Arunmozhiarasi; Jeyaseelan, Kandiah. 2013. "Blood microRNAs in Low or No Risk Ischemic Stroke Patients." Int. J. Mol. Sci. 14, no. 1: 2072-2084.