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Int. J. Mol. Sci. 2013, 14(1), 1566-1588; doi:10.3390/ijms14011566
Review

RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis

 and
*
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
* Author to whom correspondence should be addressed.
Received: 12 December 2012 / Revised: 31 December 2012 / Accepted: 4 January 2013 / Published: 14 January 2013
(This article belongs to the Special Issue Non-Coding RNAs 2012)
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Abstract

Hematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs in leukemia.
Keywords: RUNX1 (AML1); microRNAs (miRNAs); hematopoiesis; leukemia; transcription factor-microRNA circuits; gene regulatory networks RUNX1 (AML1); microRNAs (miRNAs); hematopoiesis; leukemia; transcription factor-microRNA circuits; gene regulatory networks
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Rossetti, S.; Sacchi, N. RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci. 2013, 14, 1566-1588.

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