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Int. J. Mol. Sci. 2013, 14(1), 1566-1588; doi:10.3390/ijms14011566
Review

RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis

 and *
Received: 12 December 2012; in revised form: 31 December 2012 / Accepted: 4 January 2013 / Published: 14 January 2013
(This article belongs to the Special Issue Non-Coding RNAs 2012)
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Abstract: Hematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs in leukemia.
Keywords: RUNX1 (AML1); microRNAs (miRNAs); hematopoiesis; leukemia; transcription factor-microRNA circuits; gene regulatory networks RUNX1 (AML1); microRNAs (miRNAs); hematopoiesis; leukemia; transcription factor-microRNA circuits; gene regulatory networks
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rossetti, S.; Sacchi, N. RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci. 2013, 14, 1566-1588.

AMA Style

Rossetti S, Sacchi N. RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis. International Journal of Molecular Sciences. 2013; 14(1):1566-1588.

Chicago/Turabian Style

Rossetti, Stefano; Sacchi, Nicoletta. 2013. "RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis." Int. J. Mol. Sci. 14, no. 1: 1566-1588.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert