Open AccessThis article is
- freely available
RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
* Author to whom correspondence should be addressed.
Received: 12 December 2012; in revised form: 31 December 2012 / Accepted: 4 January 2013 / Published: 14 January 2013
Abstract: Hematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs in leukemia.
Keywords: RUNX1 (AML1); microRNAs (miRNAs); hematopoiesis; leukemia; transcription factor-microRNA circuits; gene regulatory networks
Citations to this Article
Cite This Article
MDPI and ACS Style
Rossetti, S.; Sacchi, N. RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis. Int. J. Mol. Sci. 2013, 14, 1566-1588.
Rossetti S, Sacchi N. RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis. International Journal of Molecular Sciences. 2013; 14(1):1566-1588.
Rossetti, Stefano; Sacchi, Nicoletta. 2013. "RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis." Int. J. Mol. Sci. 14, no. 1: 1566-1588.