Next Article in Journal
Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
Next Article in Special Issue
Disruption of the Expression of a Non-Coding RNA Significantly Impairs Cellular Differentiation in Toxoplasma gondii
Previous Article in Journal
Isolation and Characterisation of 11 Polymorphic Microsatellite Markers in Papaver rhoeas L. (Corn Poppy), a Major Annual Plant Species from Cultivated Areas
Previous Article in Special Issue
Exploration of the Role of the Non-Coding RNA SbrE in L. monocytogenes Stress Response
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(1), 480-495; doi:10.3390/ijms14010480

Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region

Gene Expression — Microarrays Laboratory, Bambino Gesù Children's Hospital, IRCCS, S. Onofrio 4, Rome 00165, Italy
Author to whom correspondence should be addressed.
Received: 12 November 2012 / Revised: 6 December 2012 / Accepted: 6 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Non-Coding RNAs 2012)
View Full-Text   |   Download PDF [363 KB, uploaded 19 June 2014]   |  


MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through the binding of the 3' untranslated region (3'UTR) of specific mRNAs. MiRNAs are post-transcriptional regulators and determine the repression of translation processes or the degradation of mRNA targets. Recently, another kind of miRNA-mediated regulation of translation (repression or activation) involving the binding of miRNA to the 5'UTR of target gene has been reported. The possible interactions and the mechanism of action have been reported in many works that we reviewed here. Moreover, we discussed also the available bioinformatics tools for predicting the miRNA binding sites in the 5'UTR and public databases collecting this information. View Full-Text
Keywords: miRNAs; 5'UTR; 3'UTR; bioinformatics tools; translation regulation miRNAs; 5'UTR; 3'UTR; bioinformatics tools; translation regulation

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sacco, L.D.; Masotti, A. Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region. Int. J. Mol. Sci. 2013, 14, 480-495.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top