Int. J. Mol. Sci. 2013, 14(1), 480-495; doi:10.3390/ijms14010480
Review

Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region

Gene Expression — Microarrays Laboratory, Bambino Gesù Children's Hospital, IRCCS, P.za S. Onofrio 4, Rome 00165, Italy
* Author to whom correspondence should be addressed.
Received: 12 November 2012; in revised form: 6 December 2012 / Accepted: 6 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Non-Coding RNAs 2012)
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Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through the binding of the 3' untranslated region (3'UTR) of specific mRNAs. MiRNAs are post-transcriptional regulators and determine the repression of translation processes or the degradation of mRNA targets. Recently, another kind of miRNA-mediated regulation of translation (repression or activation) involving the binding of miRNA to the 5'UTR of target gene has been reported. The possible interactions and the mechanism of action have been reported in many works that we reviewed here. Moreover, we discussed also the available bioinformatics tools for predicting the miRNA binding sites in the 5'UTR and public databases collecting this information.
Keywords: miRNAs; 5'UTR; 3'UTR; bioinformatics tools; translation regulation

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MDPI and ACS Style

Sacco, L.D.; Masotti, A. Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region. Int. J. Mol. Sci. 2013, 14, 480-495.

AMA Style

Sacco LD, Masotti A. Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region. International Journal of Molecular Sciences. 2013; 14(1):480-495.

Chicago/Turabian Style

Sacco, Letizia D.; Masotti, Andrea. 2013. "Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region." Int. J. Mol. Sci. 14, no. 1: 480-495.

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