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Long Non-Coding RNAs and p53 Regulation
Gene Expression-Microarrays Laboratory, IRCCS-Bambino Gesù Children's Hospital, Rome 00165, Italy
* Author to whom correspondence should be addressed.
Received: 5 November 2012; in revised form: 3 December 2012 / Accepted: 3 December 2012 / Published: 6 December 2012
Abstract: The advent of novel and high-throughput sequencing (next generation) technologies allowed for the sequencing of the genome at an unprecedented depth. The majority of transcribed RNAs have been classified as non-coding RNAs. Among them, long non-coding RNAs (lncRNAs) are emerging as important regulators in many biological processes. Here, we discuss the role of those lncRNAs which are under the control of p53 or that are able to regulate its activity, due to the central role of p53 pathway in many conditions. We also briefly discussed the emerging need of having novel strategies and computational tools to completely unravel the multifaceted roles of lncRNAs and to pave the way to the development of novel diagnostic and therapeutic applications based on these peculiar molecules.
Keywords: long non-coding RNAs; p53 pathway; LincRNA-p21; PANDA; H19; MEG3; LincRNA-EPS
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Baldassarre, A.; Masotti, A. Long Non-Coding RNAs and p53 Regulation. Int. J. Mol. Sci. 2012, 13, 16708-16717.
Baldassarre A, Masotti A. Long Non-Coding RNAs and p53 Regulation. International Journal of Molecular Sciences. 2012; 13(12):16708-16717.
Baldassarre, Antonella; Masotti, Andrea. 2012. "Long Non-Coding RNAs and p53 Regulation." Int. J. Mol. Sci. 13, no. 12: 16708-16717.