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Int. J. Mol. Sci. 2013, 14(1), 1105-1118; doi:10.3390/ijms14011105
Article

Identification of Recurrence Related microRNAs in Hepatocellular Carcinoma after Surgical Resection

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Received: 31 October 2012; in revised form: 11 December 2012 / Accepted: 24 December 2012 / Published: 8 January 2013
(This article belongs to the Special Issue Non-Coding RNAs 2012)
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Abstract: Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers with a high frequency of post-surgical recurrence. It is very critical to diagnose HCC recurrence at an early stage for a better therapeutic treatment. In this study, we examined the microRNA (miRNA) expression profiling in tumor tissues obtained from early and late recurrent HCC patients post-resection, using a microarray assay. A total of 32 miRNAs were identified to be differentially expressed during the progression of recurrence. Among these, 16 miRNAs were upregulated and 16 were downregulated. In addition, this miRNA expression signature was further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Moreover, functional annotation of predicted target genes of these recurrent HCC-related miRNAs indicates that multiple biological pathways (i.e., focal adhesion pathway, cancer-related pathways and mitogen-activated protein kinase (MAPK) signaling) that are all critical for cancer development and progression, may participate in the recurrence of HCC. Our data suggest potential molecular mechanisms underpinning miRNA-controlled HCC recurrence, and support the notion that miRNA expression signature and miRNA-based therapy can be useful tools for a better diagnosis and treatment stratification of this disease.
Keywords: microRNA; expression; hepatocellular carcinoma; recurrence microRNA; expression; hepatocellular carcinoma; recurrence
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yang, Z.; Miao, R.; Li, G.; Wu, Y.; Robson, S.C.; Yang, X.; Zhao, Y.; Zhao, H.; Zhong, Y. Identification of Recurrence Related microRNAs in Hepatocellular Carcinoma after Surgical Resection. Int. J. Mol. Sci. 2013, 14, 1105-1118.

AMA Style

Yang Z, Miao R, Li G, Wu Y, Robson SC, Yang X, Zhao Y, Zhao H, Zhong Y. Identification of Recurrence Related microRNAs in Hepatocellular Carcinoma after Surgical Resection. International Journal of Molecular Sciences. 2013; 14(1):1105-1118.

Chicago/Turabian Style

Yang, Zhen; Miao, Ruoyu; Li, Guangbing; Wu, Yan; Robson, Simon C.; Yang, Xiaobo; Zhao, Yi; Zhao, Haitao; Zhong, Yang. 2013. "Identification of Recurrence Related microRNAs in Hepatocellular Carcinoma after Surgical Resection." Int. J. Mol. Sci. 14, no. 1: 1105-1118.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert