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Int. J. Mol. Sci. 2010, 11(8), 2875-2900; doi:10.3390/ijms11082875

The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease

Department of Neurology, University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson AZ 85724-5023, USA
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Author to whom correspondence should be addressed.
Received: 24 May 2010 / Revised: 25 July 2010 / Accepted: 30 July 2010 / Published: 5 August 2010
(This article belongs to the Special Issue Neuroprotective Strategies (special issue))
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Abstract

Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson’s disease. View Full-Text
Keywords: neurodegeneration; VEGF-A; VEGF-B; PEDF; VEGFR1; VEGFR2; PEDF-R neurodegeneration; VEGF-A; VEGF-B; PEDF; VEGFR1; VEGFR2; PEDF-R
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Falk, T.; Gonzalez, R.T.; Sherman, S.J. The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease. Int. J. Mol. Sci. 2010, 11, 2875-2900.

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